Research Activities:  Biosensor Development

• Development of enzymatic and antibody based biosensors for clinical / environmental applications

• Synthesis of nanoparticles (inorganic, polymer and semiconductor) for immunodiagnosis and therapeutic applications.

• Design and development of antibody based immunobiosensors for monitoring various organic/inorganic/biomolecular substances.

Expertise and Synergistic Activities:

• Generation of specific antibodies (IgG and IgY types) against toxins (pesticides, aflatoxin etc),  narcotic drugs (heroin, morphine, cocaine etc.) and surface antigens (outer membrane protein, biomarkers etc) for clinical diagnosis.

• Optimization of biomolecular immobilization techniques for a stable coupling of the antibodies to the transducer surface without comprising their biological activity.

• Characterization of the bio-interface upto the molecular resolution by different physical techniques, such as Scanning Electron Microscope (SEM), Scanning Tunneling Microscope (STM), Atomic Force Microscopes (AFM), Ellipsometer etc..

• Development and standardization of  immunobiosensors systems (Optical, Microgravimetric, Micromechanical, Microfluidic and Dipstick)

• Stability analysis of immobilized enzyme/antibody for biosensor probes and

• Synthesis of nanoparticles (inorganic, semicoductor  and polymer based ) for immunodiagnosis and therapeutic applications.

Visiting Professorship/Scientist:

• North-Western University, Illinois, USA

• EPFL, Lausanne, Switzerland

• NTU, Singapore

Fellow:

• Institute of Hospital Engineering, India.

• DAAD, Germany

Member Editorial Board:

• Member-Editorial Board, J. Food, Agri. and Environment, Helsink, Finland.

• Member-Editorial Board, Research Journal of Chem. and Environment.

• Member-Editorial Board, Panjab University Research Journal of Science, Chandigarh, India.

Membership:

• Nodal officer (Chairman): Biomarker/Biosensor group,  Department of Biotechnology (Govt. of India)

• Member- Task Force (Expert  Advisory Committee) Conducting Polymer and Biosensors Department of Science & Technology (Govt. of India).

• Joint Secretary, Biosensor Society of India.

• Life Member, Biosensor Society of India

• Life Member of Biophysical Society of India.

• Member-selection committees,  IIT, CSIR and Panjabi University.

Teaching Experience:

Teaching  M.Tech students of Panjab University, Chandigarh and PhD students (JNU, Delhi) at IMTECH Chandigarh for fulfilling their partial requirement to obtain M.Tech and PhD degrees respectively.

• K V Singh, Jasdeep Kaur, Manoj Raje, Grish C Varshney & C Raman Suri٭ (2003). An ELISA based approach to optimize elution conditions for screening antibodies against hapten. Anal. & Bioanal. Chemistry. 377, 220-224
  
  
  

• Jasdeep Kaur, K V Singh, Manoj Raje, Grish C. Varshney and C Raman Suri* (2003). Strategies for direct attachment of  hapten to polystyrene support for ELISA applications.  Anal. Chim. Acta  506, 133-135.
  
  
  

• K V S Singh, Jasdeep Kaur, Grish C Varshney, Manoj Raje and C Raman Suri*  (2004) Synthesis and characterization of hapten-protein conjugates for antibody production against small molecules.  Bioconjug. Chem. 377, 220-224.
  
  
  

• Jasdeep Kaur, K V S Singh,  Ashwini Hirlekar-Schmidt, Grish C. Varshney and C Raman Suri and Manoj Raje (2004). AFM  based study of antibody pesticide interactions for characterization of immunosensor surface. Biosensors and Bioelectronics 20, 284-293.
  
  
  

• Pooja Singh, C R  Suri and S  S Cameotra (2004). Isolation of a member of Acinetobacter species involved in atrazine degradation. Biochemical and Biophysical Research Communication  317, 697-702.
  
  
  

• Schmid Hirlekar, S E Stanca, M S Thakur, K R Thampi and C R Suri*.  (2006).  Site-directed antibody immobilization on gold substrate for surface plasmon resonance sensors. Sensors and Actuators B , Vol 113, 297-303.
  
  
  

• C Raman Suri (2006). Quartz Crystal based Microgravimetric Immunobiosensors. Sensors & Transducers Vol.   66, 543-552.
  
  
  

• P C Pandey, B. Singh, R C Boro  and  C R Suri. Chemically sensitized ormosil-modified electrodes- Studies on the enhancement of selectivity in electrochemical oxidation of hydrogen peroxide" Sensors & Actuators: B.   2007, vol. 122,  30-41.
  
  
  

• Jasdeep Kaur,  K V S Singh, Robin Boro Grish C Varshney, Manoj Raje and C Raman Suri*  (2007) Environ. Science & Technology 41 (14), 5028 –5036.
  
  
  

• Jasdeep Kaur and C Raman Suri* (2007). Direct hapten coated ELISA for immunosensing of low molecular weight analytes. Nature Protocols 10.1038/nprot.2007.508 (available on line)
  
  
  

• Jasdeep Kaur, Nishima Wangoo, Kumar Rajesh and C. Raman Suri* (2008). Direct hapten coated immunoassay format for the detection of atrazine and 2,4-dichlorophenoxyacetic acid herbicides. Anal. Chim. Acta 607,  92
  
  
  

• Nishima Wangoo, K K Bhasin and C. Raman Suri*. (2008) Facile synthesis and functionalization of water-soluble gold nanoparticles for a bioprobes. Anal. Chim. Acta,  610, 142-148.
  
  
  

• Nishima Wangoo, K K Bhasin and C. Raman Suri*. (2008) Synthesis and capping of water-dispersed gold nanoparticles by an amino acid: Bioconjugation and binding studies J Collidal & Inter. Sci. Vol 323/2 pp 247-254
  
  
  

• Nishima Wangoo, G Shekhawat and C. Raman Suri*  (2008) Interaction of gold  nanoparticles with protein: A spectroscopic study to monitor protein conformational  change. Appl. Phys. Lett. 92, 133104.
  
  
  

• Sonu Gandhi, Prince Sharma and C Raman Suri* (2008) Group-selective antibodies based fluorescence immunoassay for monitoring opiate drugs. Anal. Bioanal. Chem.  392, 215-222
  
  
  

• C Raman Suri*, Jasdeep Kaur, Sonu Gandhi and Gajendra S Shekhawat (2008) Label-free ultra-sensitive detection of atrazine based on nanomechanics.  Nanotechnology 19 235502
  
  
  

• C. Raman Suri*, Robin Boro, Yogesh Nangia, Sonu Gandhi, Priyanka Sharma,  Nishima Wangoo, Kumar Rajesh (2008). Advances in immunoanalytical techniques for the analysis of pesticides in the environment. Trends in Anal. Chem. 28, 29-39.
  
  
  

• Robin Boro, K Vikas Singh and C Raman Suri* (2009) . Characterization of hapten-protein conjugates: Antibody generation and immunoassay development for chlorophenoxyacetic acid pesticides. J AOAC Int.  (In press).
  
  
  

• Yogesh Nangia, Nishima Wangoo, Saurabh Sharma, Jin-Song Wu, Vinayak Dravid,   G S Shekhawat, and C Raman Suri* (2009) Facile biosynthesis of phosphate capped gold nanoparticles by a bacterial isolate Stenotrophomonas maltophilia Appl. Phys. Lett.  (In Press).
  
  

• Immunosensors for pesticides monitoring. Advances in Biosensors (Elsevier publication). Eds. APF Turner and BD Malhotra Vol. 5, pp 161-178.
  
  
  

• Immunosensor for Pesticide Analysis. Nature News India (Macmillan Press)
  
  

• Microporous filtration based dot immunoassay device for method of screening of analytes and method of use.  Chander Raman Suri, Grish Chandra Varshney and Manoj Raje  (US patent application no. 10/393404/2003).
  
  
  

• An efficient and improved method for screening of organic molecules by microporous filtration based dot immunoassay kit.  Chander Raman Suri, Grish Chandra Varshney and Manoj Raje  (EP Patent No. 159211 B1) dated 21-02-2007 (PCT/IB2002/005607).
  
  
  

• An efficient and improved method for screening of organic molecules by microporous filtration based dot immunoassay kit.  Chander Raman Suri, Grish Chandra Varshney and Manoj Raje  (AU Patent No. 2002348763 B2)  dated 16-02-2007 WIPO No. WO04/057332)
  
  
  

• A process for the attachment of hapten to polystyrene for immuno-affinity applications Inventors:  Chander Raman Suri, Jasdeep Kaur, Kanwar Vikas Singh, Grish Chandra Varshney and Manoj Raje . Ref. No. 0049/NF/2003.
  
  
  

• C.R.Suri, Jasdeep Kaur, et al . A dipstic based immunoassay for pesticide monitoring. Application file no. 1983DEL2005
  
  
  

• C.R.Suri, Jasdeep Kaur,  et al . An immunoconjugate and process for preparation thereof. PCT International and US patent application No. 11/252621.