1AW7 Toxin date Oct 11, 1997
title Q136a Mutant Of Toxic Shock Syndrome Toxin-1 From S. Aureus
authors C.A.Earhart, D.T.Mitchell, D.L.Murray, D.M.Pinheiro, M.Matsumura, P.M.Schlievert, D.H.Ohlendorf
compound source
Molecule: Toxic Shock Syndrome Toxin-1
Chain: A, B, C, D
Synonym: Tsst-1
Engineered: Yes
Mutation: Yes
 Organism_scientific: Staphylococcus Aureus
symmetry Space Group: P 1
R_factor 0.176
crystal
cell
length a length b length c angle alpha angle beta angle gamma
49.630 99.280 41.330 88.50 93.30 91.10
method X-Ray Diffractionresolution 1.95 Å
related structures by homologous chain: 1TS3, 3TSS
similarity Belongs to the staphylococcal/streptococcal toxin family.[Stap_Strp_toxin]
subcellular loc. Secreted protein.
Gene TST (S. aureus)
function Responsible for the symptoms of toxic shock syndrome.
Gene
Ontology
ChainFunctionProcessComponent
A, D, C, B
  • pathogenesis
  • extracellular region
    • Primary referenceStructures of five mutants of toxic shock syndrome toxin-1 with reduced biological activity., Earhart CA, Mitchell DT, Murray DL, Pinheiro DM, Matsumura M, Schlievert PM, Ohlendorf DH, Biochemistry 1998 May 19;37(20):7194-202. PMID:9585531
    Data retrieval
  • Asymmetric unit, PDB entry: [header only] [complete with coordinates] (136 Kb) [Save to disk]
  • Biological Unit Coordinates (1aw7.pdb1.gz) 39 Kb
  • Biological Unit Coordinates (1aw7.pdb2.gz) 33 Kb
  • Biological Unit Coordinates (1aw7.pdb3.gz) 34 Kb
  • Biological Unit Coordinates (1aw7.pdb4.gz) 34 Kb
  • CSU: Contacts of Structural Units for 1AW7
  • Likely Quarternary Molecular Structure file(s) for 1AW7
  • Retrieve 1AW7 in mmCIF format [Save to disk]
    • View 1AW7 in 3D
  • Proteopedia, because life has more than 2D.
  • On Jmol, a nice Rasmol like molecule viewer. This is good for easiest viewing of basic structure.
  • On FirstGlance, an excellent tool for a guided tour on the structure components, by E. Martz.
  • On AstexViewer, from MSD-EBI (viewer documentation).
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    • Visual 3D analysis of 1AW7
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  • Cartoon representation from PDB Cartoon
  • Ramachandran plot from PDBSum
    • Structure-derived information
  • Dipole moment, from Dipole Server at Weizmann Institute
  • Crystal Contacts, from CryCo at Weizmann Institute
  • 3D motif for 1AW7, from MSDmotif at EBI
  • Classification of representative domains in scop (Structural Classification of Proteins)
        - Domain d1aw7a1, region A:1-93 [Jmol] [rasmolscript] [script source]
        - Domain d1aw7a2, region A:94-194 [Jmol] [rasmolscript] [script source]
        - Domain d1aw7b1, region B:201-293 [Jmol] [rasmolscript] [script source]
        - Domain d1aw7b2, region B:294-394 [Jmol] [rasmolscript] [script source]
        - Domain d1aw7c1, region C:401-493 [Jmol] [rasmolscript] [script source]
        - Domain d1aw7c2, region C:494-594 [Jmol] [rasmolscript] [script source]
        - Domain d1aw7d1, region D:601-693 [Jmol] [rasmolscript] [script source]
        - Domain d1aw7d2, region D:694-794 [Jmol] [rasmolscript] [script source]
  • Fold representative 1aw7 from FSSP and Dali (Families of Structurally Similar Proteins)
  • Class (fold), Architecture (subfold), Topology, Homologous superfamily from CATH
  • Summaries and structural analyses of PDB data files from PDBSum
  • Identification of Protein Pockets & Cavities at CASTp
    • Sequence-derived information
  • View one-letter amino acid or nucleotide sequence for each chain: [1aw7_B] [1aw7_D] [1aw7_C] [1aw7_A]
    • Other resources with information on 1AW7
  • InterPro: IPR006125 , IPR006123 , IPR006173 , IPR006126
  • PDBREPORT (protein verification by WHAT_CHECK procedures)
  • MMDB (Entrez's Structure Database)
    • Movements, Movies and Images
  • Images from IMB Jena Image Library of Biological Macromolecules.

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