1C78 Hydrolase date Feb 01, 2000
title Staphylokinase (Sak) Dimer
authors Z.Rao, F.Jiang, Y.Liu, X.Zhang, Y.Chen, M.Bartlam, H.Song, Y.Ding
compound source
Molecule: Staphylokinase
Chain: A, B
Synonym: Sak
Ec: 3.4.24.29
Engineered: Yes
Organism_scientific: Staphylococcus Aureus
Organism_common: Bacteria
Expression_system: Escherichia Coli
Expression_system_common: Bacteria
Expression_system_plasmid: Vpet-11
symmetry Space Group: P 21 21 21
R_factor 0.198
crystal
cell
length a length b length c angle alpha angle beta angle gamma
43.870 59.260 102.420 90.00 90.00 90.00
method X-Ray Diffractionresolution 2.30 Å
ligand
enzyme Aureolysin;. Staphylococcus aureus neutral proteinase;. Staphylococcus aureus neutral protease. Hydrolase E.C.3.4.24.29 BRENDA
related structures by homologous chain: 1C77, 1C79
similarity Belongs to the Staphylokinase family.
subcellular loc. Secreted protein.
Gene SAK (S. aureus)
function Potent plasminogen activator that converts plasminogen into plasmin. It forms a 1. 1 complex with plasmin, which in turn activates other plasminogen molecules.
Gene
Ontology
ChainFunctionProcessComponent
A, B
  • plasminogen activator activi...


  • Primary referenceCrystal structure of a staphylokinase: variant a model for reduced antigenicity., Chen Y, Song G, Jiang F, Feng L, Zhang X, Ding Y, Bartlam M, Yang A, Ma X, Ye S, Liu Y, Tang H, Song H, Rao Z, Eur J Biochem 2002 Jan;269(2):705-11. PMID:11856331
    Data retrieval
  • Asymmetric unit, PDB entry: [header only] [complete with coordinates] (42 Kb) [Save to disk]
  • Biological Unit Coordinates (1c78.pdb1.gz) 39 Kb
  • CSU: Contacts of Structural Units for 1C78
  • Likely Quarternary Molecular Structure file(s) for 1C78
  • Retrieve 1C78 in mmCIF format [Save to disk]
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  • Dipole moment, from Dipole Server at Weizmann Institute
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  • 3D motif for 1C78, from MSDmotif at EBI
  • Classification of representative domains in scop (Structural Classification of Proteins)
        - Domain d1c78a_, region A [Jmol] [rasmolscript] [script source]
        - Domain d1c78b_, region B [Jmol] [rasmolscript] [script source]
  • Fold representative 1c78 from FSSP and Dali (Families of Structurally Similar Proteins)
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  • Sequence-derived information
  • View one-letter amino acid or nucleotide sequence for each chain: [1c78_B] [1c78_A]
  • Other resources with information on 1C78
  • InterPro: IPR004093
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