1DQZ	Immune System	date	Jan 05, 2000
title	Crystal Structure Of Antigen 85c From Mycobacterium Tuberculosis
authors	D.R.Ronning, T.Klabunde, J.C.Sacchettini, Tb Structural Genomics Consortium (Tbsgc)
compound		source
Molecule: Antigen 85-C Chain: A, B Synonym: 85c		Organism_scientific: Mycobacterium Tuberculosis Organism_common: Bacteria
symmetry	Space Group: P 21 21 21	R_factor	0.166
crystal cell	length a length b length c angle alpha angle beta angle gamma 67.718 75.947 137.388 90.00 90.00 90.00
method	X-Ray Diffraction	resolution	1.50 Å
note	1DQZ is a representative structure
similarity	Belongs to the mycobacterial a85 antigen family.[Esterase]
subcellular loc.	Membrane localization by OPM: Bacterial gram-positive acid-fast cell wall out side in side
function	Proteins of the antigen 85 complex are responsible for the high affinity of mycobacteria to fibronectin. Possesses a mycolyltransferase activity required for the biogenesis of trehalose dimycolate (cord factor), a dominant structure necessary for maintaining cell wall integrity.
Gene Ontology	Chain Function Process Component A, B acyltransferase activity transferase activity
Primary reference	Crystal structure of the secreted form of antigen 85C reveals potential targets for mycobacterial drugs and vaccines., Ronning DR, Klabunde T, Besra GS, Vissa VD, Belisle JT, Sacchettini JC, Nat Struct Biol 2000 Feb;7(2):141-6. PMID:10655617

Data retrieval

Asymmetric unit, PDB entry: [header only] [complete with coordinates] (111 Kb) [Save to disk] Biological Unit Coordinates (1dqz.pdb1.gz) 99 Kb CSU: Contacts of Structural Units for 1DQZ Likely Quarternary Molecular Structure file(s) for 1DQZ Retrieve 1DQZ in mmCIF format [Save to disk]

View 1DQZ in 3D

On Jmol, a nice Rasmol like molecule viewer. This is good for easiest viewing of basic structure. On FirstGlance, an excellent tool for a guided tour on the structure components, by E. Martz. On AstexViewer, from MSD-EBI (viewer documentation). On RasMol (Install RasMol freeware) Here's help on how to use RasMol.

Visual 3D analysis of 1DQZ

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Structure-derived information

Conformational Epitope Prediction for 1DQZ 1DQZA 1DQZB from the CEP Server. Dipole moment, from Dipole Server at Weizmann Institute Crystal Contacts, from CryCo at Weizmann Institute 3D motif for 1DQZ, from MSDmotif at EBI Classification of representative domains in scop (Structural Classification of Proteins)     - Domain d1dqza_, region A [Jmol] [rasmolscript] [script source]     - Domain d1dqzb_, region B [Jmol] [rasmolscript] [script source] Fold representative 1dqz from FSSP and Dali (Families of Structurally Similar Proteins) Class (fold), Architecture (subfold), Topology, Homologous superfamily from CATH Summaries and structural analyses of PDB data files from PDBSum Identification of Protein Pockets & Cavities at CASTp

Sequence-derived information

View one-letter amino acid or nucleotide sequence for each chain: [1dqz_B] [1dqz_A]

Other resources with information on 1DQZ

InterPro: IPR000801 PDBREPORT (protein verification by WHAT_CHECK procedures) MMDB (Entrez's Structure Database)

Movements, Movies and Images

Domain movements in 1DQZ from the Database of Macromolecular Movements. Images from IMB Jena Image Library of Biological Macromolecules.

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