1F0P Transferase date May 16, 2000
title Mycobacterium Tuberculosis Antigen 85b With Trehalose
authors D.H.Anderson, G.Harth, M.A.Horwitz, D.Eisenberg, Tb Structural Genomics Consortium (Tbsgc)
compound source
Molecule: Antigen 85-B
Chain: A
Engineered: Yes
Organism_scientific: Mycobacterium Tuberculosis
Organism_common: Bacteria
Expression_system: Mycobacterium Smegmatis
Expression_system_common: Bacteria
Expression_system_plasmid: Psmt3
symmetry Space Group: P 31 2 1
R_factor
crystal
cell
length a length b length c angle alpha angle beta angle gamma
73.210 73.210 92.544 90.00 90.00 120.00
method X-Ray Diffractionresolution 1.90 Å
ligand MES, MPD, TRE enzyme
similarity Belongs to the mycobacterial a85 antigen family.[Esterase]
subcellular loc. Secreted protein.
genes MT1934, fbpB (M. tuberculosis)
function Proteins of the antigen 85 complex are responsible for the high affinity of mycobacteria to fibronectin. Possesses a mycolyltransferase activity required for the biogenesis of trehalose dimycolate (cord factor), a dominant structure necessary for maintaining cell wall integrity.
Gene
Ontology
ChainFunctionProcessComponent
A
  • acyltransferase activity
  • transferase activity


  • Primary referenceAn interfacial mechanism and a class of inhibitors inferred from two crystal structures of the Mycobacterium tuberculosis 30 kDa major secretory protein (Antigen 85B), a mycolyl transferase., Anderson DH, Harth G, Horwitz MA, Eisenberg D, J Mol Biol 2001 Mar 23;307(2):671-81. PMID:11254389
    Data retrieval
  • Asymmetric unit, PDB entry: [header only] [complete with coordinates] (63 Kb) [Save to disk]
  • Biological Unit Coordinates (1f0p.pdb1.gz) 51 Kb
  • CSU: Contacts of Structural Units for 1F0P
  • Likely Quarternary Molecular Structure file(s) for 1F0P
  • Structure Factors (272 Kb)
  • Retrieve 1F0P in mmCIF format [Save to disk]
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  • Classification of representative domains in scop (Structural Classification of Proteins)
        - Domain d1f0pa_, region A [Jmol] [rasmolscript] [script source]
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  • Sequence-derived information
  • View one-letter amino acid or nucleotide sequence for each chain: [1f0p_A]
  • Other resources with information on 1F0P
  • InterPro: IPR000801
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