1SXT Superantigen date Nov 14, 1996
title Staphylococcal Enterotoxin Type A (Sea) Co-Crystallised With Zinc
authors S.M.Sundstrom
compound source
Molecule: Staphylococcal Enterotoxin Type A
Chain: A, B
Synonym: Sea
Engineered: Yes
Organism_scientific: Staphylococcus Aureus
Expression_system: Escherichia Coli
symmetry Space Group: P 31 2 1
R_factor 0.206
crystal
cell
length a length b length c angle alpha angle beta angle gamma
75.590 75.590 175.310 90.00 90.00 120.00
method X-Ray Diffractionresolution 2.70 Å
ligand ZN enzyme
related structures by homologous chain: 1I4G, 1I4H
similarity Belongs to the staphylococcal/streptococcal toxin family.[Stap_Strp_tox_C]
subunit Monomer.
subcellular loc. Secreted protein.
Gene ENTA (S. aureus)
function The illness characterized by high fever, hypotension, diarrhea, shock, and in some cases death. Staphylococcal enterotoxins cause the intoxication staphylococcal food poisoning syndrome.
Gene
Ontology
ChainFunctionProcessComponent
A, B
  • zinc ion binding
  • metal ion binding
  • pathogenesis
  • extracellular region
  • Primary referenceThe Co-crystal structure of staphylococcal enterotoxin type A with Zn2+ at 2.7 A resolution. Implications for major histocompatibility complex class II binding., Sundstrom M, Hallen D, Svensson A, Schad E, Dohlsten M, Abrahmsen L, J Biol Chem 1996 Dec 13;271(50):32212-6. PMID:8943278
    Data retrieval
  • Asymmetric unit, PDB entry: [header only] [complete with coordinates] (76 Kb) [Save to disk]
  • Biological Unit Coordinates (1sxt.pdb1.gz) 37 Kb
  • Biological Unit Coordinates (1sxt.pdb2.gz) 37 Kb
  • CSU: Contacts of Structural Units for 1SXT
  • Likely Quarternary Molecular Structure file(s) for 1SXT
  • Retrieve 1SXT in mmCIF format [Save to disk]
  • View 1SXT in 3D
  • Proteopedia, because life has more than 2D.
  • On Jmol, a nice Rasmol like molecule viewer. This is good for easiest viewing of basic structure.
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  • Ramachandran plot from PDBSum
  • Structure-derived information
  • Dipole moment, from Dipole Server at Weizmann Institute
  • Crystal Contacts, from CryCo at Weizmann Institute
  • 3D motif for 1SXT, from MSDmotif at EBI
  • Genome occurence of 1SXT's fold from GeneCensus
  • Classification of representative domains in scop (Structural Classification of Proteins)
        - Domain d1sxta1, region A:10-120 [Jmol] [rasmolscript] [script source]
        - Domain d1sxta2, region A:121-233 [Jmol] [rasmolscript] [script source]
        - Domain d1sxtb1, region B:10-120 [Jmol] [rasmolscript] [script source]
        - Domain d1sxtb2, region B:121-233 [Jmol] [rasmolscript] [script source]
  • Fold representative 1sxt from FSSP and Dali (Families of Structurally Similar Proteins)
  • Class (fold), Architecture (subfold), Topology, Homologous superfamily from CATH
  • Summaries and structural analyses of PDB data files from PDBSum
  • Identification of Protein Pockets & Cavities at CASTp
  • Sequence-derived information
  • View one-letter amino acid or nucleotide sequence for each chain: [1sxt_A] [1sxt_B]
  • Other resources with information on 1SXT
  • InterPro: IPR006123 , IPR006173 , IPR006177 , IPR006126
  • PDBREPORT (protein verification by WHAT_CHECK procedures)
  • MMDB (Entrez's Structure Database)
  • Movements, Movies and Images
  • Images from IMB Jena Image Library of Biological Macromolecules.

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