1TS4 Toxin date Oct 10, 1997
title Q139k Mutant Of Toxic Shock Syndrome Toxin-1 From S. Aureus
authors C.A.Earhart, D.T.Mitchell, D.L.Murray, D.M.Pinheiro, M.Matsumura, P.M.Schlievert, D.H.Ohlendorf
compound source
Molecule: Toxic Shock Syndrome Toxin-1
Chain: A, B
Synonym: Tsst-1
Engineered: Yes
Mutation: Yes
Organism_scientific: Staphylococcus Aureus
Expression_system: Staphylococcus Aureus
symmetry Space Group: H 3 2
R_factor 0.210
crystal
cell
length a length b length c angle alpha angle beta angle gamma
152.350 152.350 142.310 90.00 90.00 120.00
method X-Ray Diffractionresolution 3.40 Å
similarity Belongs to the staphylococcal/streptococcal toxin family.[Stap_Strp_toxin]
subcellular loc. Secreted protein.
Gene TST (S. aureus)
function Responsible for the symptoms of toxic shock syndrome.
Gene
Ontology
ChainFunctionProcessComponent
A, B
  • pathogenesis
  • extracellular region
  • Primary referenceStructures of five mutants of toxic shock syndrome toxin-1 with reduced biological activity., Earhart CA, Mitchell DT, Murray DL, Pinheiro DM, Matsumura M, Schlievert PM, Ohlendorf DH, Biochemistry 1998 May 19;37(20):7194-202. PMID:9585531
    Data retrieval
  • Asymmetric unit, PDB entry: [header only] [complete with coordinates] (65 Kb) [Save to disk]
  • Biological Unit Coordinates (1ts4.pdb1.gz) 32 Kb
  • Biological Unit Coordinates (1ts4.pdb2.gz) 32 Kb
  • CSU: Contacts of Structural Units for 1TS4
  • Likely Quarternary Molecular Structure file(s) for 1TS4
  • Retrieve 1TS4 in mmCIF format [Save to disk]
  • View 1TS4 in 3D
  • Proteopedia, because life has more than 2D.
  • On Jmol, a nice Rasmol like molecule viewer. This is good for easiest viewing of basic structure.
  • On FirstGlance, an excellent tool for a guided tour on the structure components, by E. Martz.
  • On AstexViewer, from MSD-EBI (viewer documentation).
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  • Visual 3D analysis of 1TS4
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  • Cartoon representation from PDB Cartoon
  • Ramachandran plot from PDBSum
  • Structure-derived information
  • Dipole moment, from Dipole Server at Weizmann Institute
  • Crystal Contacts, from CryCo at Weizmann Institute
  • 3D motif for 1TS4, from MSDmotif at EBI
  • Classification of representative domains in scop (Structural Classification of Proteins)
        - Domain d1ts4a1, region A:1-93 [Jmol] [rasmolscript] [script source]
        - Domain d1ts4a2, region A:94-194 [Jmol] [rasmolscript] [script source]
        - Domain d1ts4b1, region B:201-293 [Jmol] [rasmolscript] [script source]
        - Domain d1ts4b2, region B:294-394 [Jmol] [rasmolscript] [script source]
  • Fold representative 1ts4 from FSSP and Dali (Families of Structurally Similar Proteins)
  • Class (fold), Architecture (subfold), Topology, Homologous superfamily from CATH
  • Summaries and structural analyses of PDB data files from PDBSum
  • Identification of Protein Pockets & Cavities at CASTp
  • Sequence-derived information
  • View one-letter amino acid or nucleotide sequence for each chain: [1ts4_B] [1ts4_A]
  • Other resources with information on 1TS4
  • InterPro: IPR006125 , IPR006123 , IPR006173 , IPR006126
  • PDBREPORT (protein verification by WHAT_CHECK procedures)
  • MMDB (Entrez's Structure Database)
  • Movements, Movies and Images
  • Images from IMB Jena Image Library of Biological Macromolecules.

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