1WA8 Tuberculosis date Oct 25, 2004
title Solution Structure Of The Cfp-10.Esat-6 Complex. Major Virulence Determinants Of Pathogenic Mycobacteria
authors P.S.Renshaw, K.L.Lightbody, V.Veverka, F.W.Muskett, G.Kelly, T.A.Frenkiel, S.V.Gordon, R.G.Hewinson, B.Burke, J.Norman, R.A.Williamson, M.D.Carr, Tb Structural Genomics Consortium (Tbsgc)
compound source
Molecule: Esat-6 Like Protein Esxb
Synonym: 10 Kda Culture Filtrate Antigen Cfp10, Secreted Antigenic Protein Mtsa-10;
Chain: A
Fragment: Residues 1-99
Engineered: Yes
Other_details: Produced Minus The N-Terminal Met
 Expression_system: Escherichia Coli
Expression_system_strain: Bl21(De3)
Expression_system_plasmid: Pet21a
Organism_scientific: Mycobacterium Bovis
Strain: An5

Molecule: 6 Kda Early Secretory Antigenic Target (Esat-6)
Synonym: Esat-6
Chain: B
Fragment: Residues 1-95
Engineered: Yes
Expression_system: Escherichia Coli
Expression_system_strain: Bl21(De3)
Expression_system_plasmid: Pet28a
Organism_scientific: Mycobacterium Tuberculosis
Strain: H37rv
methodNMR, 28 Structures
note 1WA8 is a representative structure
Primary referenceStructure and function of the complex formed by the tuberculosis virulence factors CFP-10 and ESAT-6., Renshaw PS, Lightbody KL, Veverka V, Muskett FW, Kelly G, Frenkiel TA, Gordon SV, Hewinson RG, Burke B, Norman J, Williamson RA, Carr MD, EMBO J. 2005 Jul 20;24(14):2491-8. Epub 2005 Jun 23. PMID:15973432
Data retrieval
  • Asymmetric unit, PDB entry: [header only] [complete with coordinates] (1238 Kb) [Save to disk]
  • Biological Unit Coordinates (1wa8.pdb1.gz) 1311 Kb
  • CSU: Contacts of Structural Units for 1WA8
  • Original NMR restraints for 1WA8 from PDB
  • Parsed, converted and filtered NMR Restraints for 1WA8 in BioMagResBank (BMRB)
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