1YQY Hydrolase date Feb 02, 2005
title Structure Of B. Anthrax Lethal Factor In Complex With A Hydroxamate Inhibitor
authors W.L.Shoop, Y.Xiong, J.Wiltsie, A.Woods, J.Guo, J.V.Pivnichny, T.Felcetto, B.F.Michael, A.Bansal
compound source
Molecule: Lethal Factor
Chain: A
Fragment: Domains II-Iv (Residues 297-809)
Synonym: Lf, Anthrax Lethal Toxin Endopeptidase Component
Ec: 3.4.24.83
Engineered: Yes
 Organism_scientific: Bacillus Anthracis
Organism_common: Bacteria
Gene: Lef
Expression_system: Escherichia Coli
Expression_system_common: Bacteria
Expression_system_strain: Bl21(De3)
Expression_system_vector_type: Plasmid
Expression_system_plasmid: Pgex-4t-3
symmetry Space Group: P 21 21 21
R_factor 0.191
crystal
cell
length a length b length c angle alpha angle beta angle gamma
57.332 75.957 139.006 90.00 90.00 90.00
method X-Ray Diffractionresolution 2.30 Å
ligand 915, ZN enzyme Hydrolase E.C.3.4.24.83 BRENDA
note 1YQY is a representative structure
Gene
Ontology
ChainFunctionProcessComponent
A
  • peptidase activity
  • metallopeptidase activity
  • zinc ion binding
  • hydrolase activity
  • metal ion binding
  • proteolysis
  • pathogenesis
  • extracellular region
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  • Asymmetric unit, PDB entry: [header only] [complete with coordinates] (107 Kb) [Save to disk]
  • Biological Unit Coordinates (1yqy.pdb1.gz) 94 Kb
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