2A5D	Protein Transport Transferase	date	Jun 30, 2005
title	Structural Basis For The Activation Of Cholera Toxin By Human Arf6-Gtp
authors	C.J.O'Neal, M.G.Jobling, R.K.Holmes, W.G.J.Hol
compound		source
Molecule: Adp-Ribosylation Factor 6 Chain: A Engineered: Yes		Organism_scientific: Homo Sapiens Organism_common: Human Gene: Arf6 Expression_system: Escherichia Coli Expression_system_common: Bacteria Expression_system_strain: Bl21(De3)
Molecule: Cholera Enterotoxin, A Chain Chain: B Fragment: A1 Subunit Synonym: Nad(+)--Diphthamide Adp-Ribosyltransferase, Cholera Enterotoxin A Subunit; Ec: 2.4.2.36 Engineered: Yes Mutation: Yes		Organism_scientific: Vibrio Cholerae Gene: Ctxa, Toxa Expression_system: Escherichia Coli Expression_system_common: Bacteria Expression_system_strain: Bl21(De3)
symmetry	Space Group: P 21 21 21	R_factor	0.167
crystal cell	length a length b length c angle alpha angle beta angle gamma 44.915 91.446 98.547 90.00 90.00 90.00
method	X-Ray Diffraction	resolution	1.80 Å
ligand	GOL, GTP, MG, NA	enzyme	Transferase E.C.2.4.2.36 BRENDA
Gene Ontology	Chain Function Process Component A nucleotide binding protein binding GTP binding transport ER to Golgi vesicle-mediated... cell motility cell adhesion small GTPase mediated signal... protein transport vesicle-mediated transport positive regulation of actin... cortical actin cytoskeleton ... ruffle organization and biog... regulation of Rac protein si... negative regulation of recep... ruffle endosome Golgi stack plasma membrane cell cortex B catalytic activity transferase activity transferase activity, transf... NAD+-diphthamide ADP-ribosyl... pathogenesis extracellular region

Data retrieval

Asymmetric unit, PDB entry: [header only] [complete with coordinates] (78 Kb) [Save to disk] Biological Unit Coordinates (2a5d.pdb1.gz) 63 Kb CSU: Contacts of Structural Units for 2A5D Likely Quarternary Molecular Structure file(s) for 2A5D Structure Factors (581 Kb) Retrieve 2A5D in mmCIF format [Save to disk]

View 2A5D in 3D

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Visual 3D analysis of 2A5D

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Structure-derived information

Electron Density related parameters from EDS Electron Density Server, at Upsala Dipole moment, from Dipole Server at Weizmann Institute Crystal Contacts, from CryCo at Weizmann Institute 3D motif for 2A5D, from MSDmotif at EBI Fold representative 2a5d from FSSP and Dali (Families of Structurally Similar Proteins)

Sequence-derived information

View one-letter amino acid or nucleotide sequence for each chain: [2a5d_B] [2a5d_A]

Other resources with information on 2A5D

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