2B35	Oxidoreductase	date	Sep 19, 2005
title	Crystal Structure Of Mycobacterium Tuberculosis Enoyl Reductase (Inha) Inhibited By Triclosan
authors	T.J.Sullivan, J.J.Truglio, P.Novichenok, C.Stratton, X.Zhang, T.Kaur, F.Johnson, M.S.Boyne, A.Amin
compound		source
Molecule: Enoyl-[Acyl-Carrier-Protein] Reductase [Nadh] Chain: A, B, C, D, E, F Synonym: Nadh-Dependent Enoyl-Acp Reductase Ec: 1.3.1.9 Engineered: Yes		Organism_scientific: Mycobacterium Tuberculosis Gene: Inha Expression_system: Escherichia Coli Expression_system_common: Bacteria
symmetry	Space Group: C 1 2 1	R_factor	0.268
crystal cell	length a length b length c angle alpha angle beta angle gamma 99.955 81.827 188.656 90.00 95.69 90.00
method	X-Ray Diffraction	resolution	2.30 Å
ligand	NAD, TCL	enzyme	Oxidoreductase E.C.1.3.1.9 BRENDA
Gene Ontology	Chain Function Process Component F, A, D, C, E, B enoyl-[acyl-carrier-protein]... oxidoreductase activity fatty acid biosynthetic proc... metabolic process lipid biosynthetic process response to antibiotic

Data retrieval

Asymmetric unit, PDB entry: [header only] [complete with coordinates] (264 Kb) [Save to disk] Biological Unit Coordinates (2b35.pdb1.gz) 155 Kb Biological Unit Coordinates (2b35.pdb2.gz) 157 Kb CSU: Contacts of Structural Units for 2B35 Likely Quarternary Molecular Structure file(s) for 2B35 Structure Factors (1354 Kb) Retrieve 2B35 in mmCIF format [Save to disk]

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Structure-derived information

Electron Density related parameters from EDS Electron Density Server, at Upsala Dipole moment, from Dipole Server at Weizmann Institute Crystal Contacts, from CryCo at Weizmann Institute 3D motif for 2B35, from MSDmotif at EBI Fold representative 2b35 from FSSP and Dali (Families of Structurally Similar Proteins)

Sequence-derived information

View one-letter amino acid or nucleotide sequence for each chain: [2b35_A] [2b35_F] [2b35_E] [2b35_C] [2b35_B] [2b35_D]

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