2B36 Oxidoreductase date Sep 19, 2005
title Crystal Structure Of Mycobacterium Tuberculosis Enoyl Reductase (Inha) Inhibited By 5-Pentyl-2-Phenoxyphenol
authors T.J.Sullivan, J.J.Truglio, P.Novichenok, C.Stratton, X.Zhang, T.Kaur, F.Johnson, M.S.Boyne, A.Amin
compound source
Molecule: Enoyl-[Acyl-Carrier-Protein] Reductase [Nadh]
Chain: A, B, C, D, E, F
Synonym: Nadh-Dependent Enoyl-Acp Reductase
Ec: 1.3.1.9
Engineered: Yes
Organism_scientific: Mycobacterium Tuberculosis
Gene: Inha
Expression_system: Escherichia Coli
Expression_system_common: Bacteria
symmetry Space Group: C 1 2 1
R_factor 0.242
crystal
cell
length a length b length c angle alpha angle beta angle gamma
99.955 81.827 188.656 90.00 95.69 90.00
method X-Ray Diffractionresolution 2.80 Å
ligand 5PP, NAD enzyme Oxidoreductase E.C.1.3.1.9 BRENDA
Gene
Ontology
ChainFunctionProcessComponent
F, A, D, C, E, B
  • enoyl-[acyl-carrier-protein]...
  • oxidoreductase activity
  • fatty acid biosynthetic proc...
  • metabolic process
  • lipid biosynthetic process
  • response to antibiotic

  • Data retrieval
  • Asymmetric unit, PDB entry: [header only] [complete with coordinates] (271 Kb) [Save to disk]
  • Biological Unit Coordinates (2b36.pdb1.gz) 164 Kb
  • Biological Unit Coordinates (2b36.pdb2.gz) 160 Kb
  • CSU: Contacts of Structural Units for 2B36
  • Likely Quarternary Molecular Structure file(s) for 2B36
  • Structure Factors (869 Kb)
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  • Fold representative 2b36 from FSSP and Dali (Families of Structurally Similar Proteins)
  • Sequence-derived information
  • View one-letter amino acid or nucleotide sequence for each chain: [2b36_D] [2b36_A] [2b36_F] [2b36_E] [2b36_C] [2b36_B]
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