2C4L Hydrolase date Oct 20, 2005
title Structure Of Neuraminidase Subtype N9 Complexed With 30 Mm Sialic Acid (Nana, Neu5ac), Crystal Soaked For 24 Hours At 291 K And Finally Backsoaked For 30 Min In A Cryoprotectant Solution Which Did Not Contain Neu5ac
authors E.Rudino-Pinera, P.Tunnah, S.J.Crennell, R.G.Webster, W.G.Laver, E.F.Garman
compound source
Molecule: Neuraminidase Subtype N9
Chain: A
Fragment: Residues 83-470
Ec: 3.2.1.18
Engineered: Yes
Organism_scientific: Influenza A Virus
Organism_common: Avian Influenza Virus A
Organism_taxid: 11320
Strain: Aternsterna Albifronsn9
Expression_system: Gallus Gallus
Expression_system_taxid: 9031
symmetry Space Group: I 4 3 2
R_factor 0.155 R_Free 0.196
crystal
cell
length a length b length c angle alpha angle beta angle gamma
181.178 181.178 181.178 90.00 90.00 90.00
method X-Ray Diffractionresolution 2 Å
ligand BMA, CA, MAN, NAG, SIA enzyme Hydrolase E.C.3.2.1.18 BRENDA
Gene NA
Gene
Ontology
ChainFunctionProcessComponent
A
  • exo-alpha-sialidase activity...
  • calcium ion binding
  • hydrolase activity
  • hydrolase activity, acting o...
  • metal ion binding
  • carbohydrate metabolic proce...
  • metabolic process
  • plasma membrane
  • membrane
  • integral to membrane
  • virion
  • host cell plasma membrane
  • virion membrane
  • Data retrieval
  • Asymmetric unit, PDB entry: [header only] [complete with coordinates] (80 Kb) [Save to disk]
  • Biological Unit Coordinates (2c4l.pdb1.gz) 277 Kb
  • CSU: Contacts of Structural Units for 2C4L
  • Likely Quarternary Molecular Structure file(s) for 2C4L
  • Structure Factors (243 Kb)
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  • Sequence-derived information
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