2SAK Plasminogen Activator date Feb 20, 1997
title Staphylokinase (Sakstar Variant)
authors A.Rabijns, H.L.De Bondt, M.De Maeyer, I.Lasters, C.De Ranter
compound source
Molecule: Staphylokinase
Chain: A
Mutation: Yes
Organism_scientific: Staphylococcus Aureus
symmetry Space Group: C 1 2 1
R_factor 0.181
crystal
cell
length a length b length c angle alpha angle beta angle gamma
60.600 43.730 54.270 90.00 115.63 90.00
method X-Ray Diffractionresolution 1.80 Å
ligand TRS enzyme
note 2SAK is a representative structure
related structures by homologous chain: 1C76
similarity Belongs to the Staphylokinase family.
subcellular loc. Secreted protein.
Gene SAK (S. aureus)
function Potent plasminogen activator that converts plasminogen into plasmin. It forms a 1. 1 complex with plasmin, which in turn activates other plasminogen molecules.
Gene
Ontology
ChainFunctionProcessComponent
A
  • plasminogen activator activi...


  • Primary referenceThree-dimensional structure of staphylokinase, a plasminogen activator with therapeutic potential., Rabijns A, De Bondt HL, De Ranter C, Nat Struct Biol 1997 May;4(5):357-60. PMID:9145104
    Data retrieval
  • Asymmetric unit, PDB entry: [header only] [complete with coordinates] (25 Kb) [Save to disk]
  • Biological Unit Coordinates (2sak.pdb1.gz) 42 Kb
  • CSU: Contacts of Structural Units for 2SAK
  • Likely Quarternary Molecular Structure file(s) for 2SAK
  • Retrieve 2SAK in mmCIF format [Save to disk]
  • View 2SAK in 3D
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  • Structure-derived information
  • Dipole moment, from Dipole Server at Weizmann Institute
  • Crystal Contacts, from CryCo at Weizmann Institute
  • 3D motif for 2SAK, from MSDmotif at EBI
  • Genome occurence of 2SAK's fold from GeneCensus
  • Classification of representative domains in scop (Structural Classification of Proteins)
        - Domain d2sak__, region [Jmol] [rasmolscript] [script source]
  • Fold representative 2sak from FSSP and Dali (Families of Structurally Similar Proteins)
  • Class (fold), Architecture (subfold), Topology, Homologous superfamily from CATH
  • Summaries and structural analyses of PDB data files from PDBSum
  • Identification of Protein Pockets & Cavities at CASTp
  • Sequence-derived information
  • View one-letter amino acid or nucleotide sequence for each chain: [2sak_A]
  • Other resources with information on 2SAK
  • InterPro: IPR004093
  • PDBREPORT (protein verification by WHAT_CHECK procedures)
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