1DGG | Oxidoreductase | date | Nov 24, 1999 | ||||||||||||
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title | Human Erythrocyte Catalse Cyanide Complex | ||||||||||||||
authors | C.D.Putnam, A.S.Arvai, Y.Bourne, J.A.Tainer | ||||||||||||||
compound | source | ||||||||||||||
Molecule: Catalase Chain: A, B, C, D Ec: 1.11.1.6 |
Organism_scientific: Homo Sapiens Organism_common: Human Cell: Erythrocyte | ||||||||||||||
symmetry | Space Group: P 21 21 21 | R_factor | 0.178 | ||||||||||||
crystal cell |
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method | X-Ray Diffraction | resolution | 1.80 Å | ||||||||||||
ligand | CYN, HEM, NDP | enzyme | Oxidoreductase E.C.1.11.1.6 | ||||||||||||
related structures | by homologous chain: 1DGF, 1DGH | ||||||||||||||
similarity | Belongs to the catalase family. | ||||||||||||||
subunit | Homotetramer. | ||||||||||||||
catalytic activ. | 2 h(2)o(2) = o(2) + 2 h(2)o. | ||||||||||||||
subcellular loc. | Peroxisomal. | ||||||||||||||
gene | CAT (H. sapiens) | ||||||||||||||
function | Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide. | ||||||||||||||
Gene Ontology | chain A: GO:0004096, GO:0004601, GO:0005777, GO:0006118, GO:0006979, GO:0016491 chain B: GO:0004096, GO:0004601, GO:0005777, GO:0006118, GO:0006979, GO:0016491 chain C: GO:0004096, GO:0004601, GO:0005777, GO:0006118, GO:0006979, GO:0016491 chain D: GO:0004096, GO:0004601, GO:0005777, GO:0006118, GO:0006979, GO:0016491 | ||||||||||||||
disease | Acatalasemia This disease is characterized by absence of catalase activity in red cells and is often associated with ulcerating oral lesions. Defects in cat are the cause of acatalasia [mim. 115500]; also known as acatalasemia. | ||||||||||||||
Primary reference | Active and inhibited human catalase structures: ligand and NADPH binding and catalytic mechanism., Putnam CD, Arvai AS, Bourne Y, Tainer JA, J Mol Biol 2000 Feb 11;296(1):295-309. PMID:10656833 |
Data retrieval |
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Structure-derived information |
- Domain d1dgga_, region A [Jmol] [rasmolscript] [script source] - Domain d1dggb_, region B [Jmol] [rasmolscript] [script source] - Domain d1dggc_, region C [Jmol] [rasmolscript] [script source] - Domain d1dggd_, region D [Jmol] [rasmolscript] [script source] |
Sequence-derived information |
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