1IAT | Isomerase | date | Mar 23, 2001 | ||||||||||||
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title | Crystal Structure Of Human Phosphoglucose Isomeraseneuroleukinautocrine Motility Factormaturation Factor | ||||||||||||||
authors | J.A.Read, J.Pearce, X.Li, H.Muirhead, J.Chirgwin, C.Davies | ||||||||||||||
compound | source | ||||||||||||||
Molecule: Phosphoglucose Isomerase Chain: A Synonym: Glucose-6-Phosphate Isomerase, Glucose Phosphate Isomerase; Ec: 5.3.1.9 Engineered: Yes |
Organism_scientific: Homo Sapiens Organism_common: Human Gene: Gpi Expression_system: Escherichia Coli Expression_system_common: Bacteria | ||||||||||||||
symmetry | Space Group: P 43 21 2 | R_factor | 0.144 | ||||||||||||
crystal cell |
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method | X-Ray Diffraction | resolution | 1.62 Å | ||||||||||||
ligand | SUL, BME | enzyme | Glucose-6-phosphate isomerase. Phosphohexose isomerase. Phosphohexomutase. Oxoisomerase. Hexosephosphate isomerase. Phosphosaccharomutase. Phosphoglucoisomerase. Phosphohexoisomerase. Phosphoglucose isomerase. Glucose phosphate isomerase. Hexose phosphate. Isomerase E.C.5.3.1.9 | ||||||||||||
note | 1IAT is a representative structure | ||||||||||||||
related structures | by homologous chain: 1HM5 | ||||||||||||||
similarity | Belongs to the gpi family.[PGI] | ||||||||||||||
subunit | Homodimer. | ||||||||||||||
catalytic activ. | D-glucose 6-phosphate = d-fructose 6- phosphate. | ||||||||||||||
pathway | Involved in glycolysis and in gluconeogenesis. | ||||||||||||||
subcellular loc. | Cytoplasmic. | ||||||||||||||
genes | PGIB (B. stearothermophilus); GPI (H. sapiens); GPI (S. scrofa); PF0196, PGIA (P. furiosus); GPI (O. cuniculus) | ||||||||||||||
function | Neuroleukin is a neurotrophic factor for spinal and sensory neurons. | ||||||||||||||
Gene Ontology | chain A: GO:0004347, GO:0005125, GO:0005975, GO:0006094, GO:0006096, GO:0006959, GO:0007399, GO:0007599, GO:0008083, GO:0016853 | ||||||||||||||
disease | Hemolytic anemia due to glucosephosphate isomerase deficiency Hydrops fetalis,one form Defects in gpi are a cause of hereditary nonspherocytic hemolytic anemia (ha) [mim. 172400]. Severe gpi deficiency can be associated with hydrops fetalis, immediate neonatal death and neurological impairment. | ||||||||||||||
Primary reference | The crystal structure of human phosphoglucose isomerase at 1.6 A resolution: implications for catalytic mechanism, cytokine activity and haemolytic anaemia., Read J, Pearce J, Li X, Muirhead H, Chirgwin J, Davies C, J Mol Biol 2001 Jun 1;309(2):447-63. PMID:11371164 |
Data retrieval |
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Structure-derived information |
- Domain d1iata_, region A [Jmol] [rasmolscript] [script source] |
Sequence-derived information |
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