2OAT Aminotransferase date May 07, 1998
title Ornithine Aminotransferase Complexed With 5-Fluoromethylornithine
authors P.Storici, G.Capitani, R.Muller, T.Schirmer, J.N.Jansonius
compound source
Molecule: Ornithine Aminotransferase
Chain: A, B, C
Ec: 2.6.1.13
Engineered: Yes
Biological_unit: Homotetramer
 Organism_scientific: Homo Sapiens
Organism_common: Human
Organ: Liver
Organelle: Mitochondria
Cellular_location: Intramitochondria
Gene: Oat
Expression_system: Escherichia Coli
Expression_system_strain: Tb1
Expression_system_plasmid: Pmal-C2
symmetry Space Group: P 32 2 1
R_factor 0.204
crystal
cell
length a length b length c angle alpha angle beta angle gamma
115.280 115.280 186.810 90.00 90.00 120.00
method X-Ray Diffractionresolution 1.95 Å
ligand PFMenzyme Ornithine-oxo-acid transaminase. Ornithine d-transaminase. L-ornithine. Alpha-ketoglutarate d-aminotransferase. OAT. L-ornithine 5-aminotransferase. L-ornithine aminotransferase. Ornithine 5-aminotransferase. Ornithine transaminase. Ornithine-alpha-ketoglutarate aminotransferase. Ornithine-2-oxoacid aminotransferase. Ornithine-keto acid aminotransferase. Ornithine-keto acid transaminase. Ornithine-ketoglutarate aminotransferase. Ornithine-oxo acid aminotransferase. Ornithine. Alpha-oxoglutarate transaminase. Transferase E.C.2.6.1.13
note 2OAT is a representative structure
related structures by homologous chain: 1GBN
similarity Belongs to class-iii of pyridoxal-phosphate-dependent aminotransferases.[aminotran_3]
subunit Homotetramer.
catalytic activ. L-ornithine + a 2-oxo acid = l-glutamate 5- semialdehyde + an l-amino acid.
subcellular loc. Mitochondrial matrix.
gene OAT (H. sapiens)
disease Gyrate atrophy of choroid and retina with ornithinemia,B6responsive or unresponsive
Defects in oat are the cause of ornithinemia with gyrate atrophy (ga) of choroid and retina. Ga is a slowly progressive blinding autosomal recessive disorder.
Data retrieval
  • Asymmetric unit, PDB entry: [header only] [complete with coordinates] (229 Kb) [Save to disk]
  • LPC: Ligand-Protein Contacts for 2OAT
  • CSU: Contacts of Structural Units for 2OAT
  • Likely Quarternary Molecular Structure file(s) for 2OAT
  • Retrieve 2OAT in mmCIF format [Save to disk]
    • View 2OAT in 3D
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    • Visual 3D analysis of 2OAT
  • STING, shows the sequence and maps the locations of sequence residues or residue ranges onto the 3D structure.
  • Noncovalent Bond Finder displays the closest contacts to ligand or interface, reports distances, walks over water bridges.
  • GRASS (Graphical Representation and Analysis of Structure Server)
  • Cartoon representation from PDB Cartoon
    • Structure-derived information
  • Dipole moment, from Dipole Server at Weizmann Institute
  • Classification of representative domains in scop (Structural Classification of Proteins)
        - Domain d2oata_, region A: [rasmolscript] [script source]
        - Domain d2oatb_, region B: [rasmolscript] [script source]
        - Domain d2oatc_, region C: [rasmolscript] [script source]
  • Fold representative 2oat from FSSP and Dali (Families of Structurally Similar Proteins)
  • Class (fold), Architecture (subfold), Topology, Homologous superfamily: CATH
  • Summaries and structural analyses of PDB data files: PDBSum
    • Sequence-derived information
  • View one-letter amino acid or nucleotide sequence for each chain: [2oat_A] [2oat_B] [2oat_C]
  • SWISS-PROT database: [OAT_HUMAN]
  • Domain organization of [OAT_HUMAN] by SWISSPFAM
  • Conserved protein region description, domain view and alignment from family aminotran_3 (PF00202) of Pfam.
  • Alignments of the sequence of 2OAT with the sequences similar proteins can be viewed for classification [OAT_HUMAN] at ProtoMap. Click on "Neighbors List", then on the "See Alignments" button below the list.
  • A sequence distance tree ("phylogenetic tree") can be viewed for 1ACL's classification [OAT_HUMAN] at ProtoMap. Click on the Cluster number.
    • Other resources with information on 2OAT
  • InterPro: IPR005814
  • PDBREPORT (protein verification by WHAT_CHECK procedures)
  • MMDB (Entrez's Structure Database)
    • Movements, Movies and Images
  • Images from IMB Jena Image Library of Biological Macromolecules.

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