(I)CLUSTAL X (1.81) multiple sequence alignment(activate adenylate cyclase) P43530 --MKNITFIFFILLASPLYANGDKLYRADSRPPDEIKRSGGLMPRGHNEYFDRGTQMNIN P06717 --MKNITFIFFILLASPLYANGDRLYRADSRPPDEIKRSGGLMPRGHNEYFDRGTQMNIN P01555 --MVKIIFVFFIFLSSFSYANDDKLYRADSRPPDEIKQSGGLMPRGQSEYFDRGTQMNIN P13810 --MIKHVLLFFVFISFSVSAN--DFFRADSRTPDEIRRAGGLLPRGQQEAYERGTPININ P43528 MAKVISFFISLFLISFPLYAN--DYFRADSRTPDEVRRSGGLIPRGQDEAYERGTPININ :: :.::: ** :*****.***::::***:***:.* ::*** :*** P43530 LYDHARGTQTGFVRYDDGYVSTSLSLRSAHLAGQSILSGYSTYYIYVIATAPNMFNVNDV P06717 LYDHARGTQTGFVRYDDGYVSTSLSLRSAHLAGQSILSGYSTYYIYVIATAPNMFNVNDV P01555 LYDHARGTQTGFVRHDDGYVSTSISLRSAHLVGQTILSGHSTYYIYVIATAPNMFNVNDV P13810 LYEHARGTVTGNTRYNDGYVSTTVTLRQAHLIGQNILGSYNEYYIYVVAPAPNLFDVNGV P43528 LYDHARGTATGNTRYNDGYVSTTTTLRQAHLLGQNMLGGYNEYYIYVVAAAPNLFDVNGV **:***** ** .*::******: :**.*** **.:*..:. *****:*.***:*:**.* P43530 LGVYSPHPYEQEVSALGGIPYSQIYGWYRVNFGVIDERLHRNREYRDRYYRNLNIAPAED P06717 LGVYSPHPYEQEVSALGGIPYSQIYGWYRVNFGVIDERLHRNREYRDRYYRNLNIAPAED P01555 LGAYSPHPDEQEVSALGGIPYSQIYGWYRVHFGVLDEQLHRNRGYRDRYYSNLDIAPAAD P13810 LGRYSPYPSENEFAALGGIPLSQIIGWYRVSFGAIEGGMQRNRDYRGDLFRGLTVAPNED P43528 LGRYSPYPSENEYAALGGIPLSQIIGWYRVSFGAIEGGMHRNRDYRRDLFRGLSAAPNED ** ***:* *:* :****** *** ***** **.:: ::*** ** : .* ** * P43530 GYRLAGFPPDHQAWREEPWIHHAPQGCGNSSRTITGDTCNEETQNLSTIYLRKYQSKVKR P06717 GYRLAGFPPDHQAWREEPWIHHAPQGCGNSSRTITGDTCNEETQNLSTIYLREYQSKVKR P01555 GYGLAGFPPEHRAWREEPWIHHAPPGCGNAPRSSMSNTCDEKTQSLGVKFLDEYQSKVKR P13810 GYQLAGFPSNFPAWREMPWSTFAPEQCVPNNKEFKGGVCISATNVLSKYDLMNFKKLLKR P43528 GYRIAGFPDGFPAWEEVPWREFAPNSCLPNNKASSDTTCASLTNKLSQHDLADFKKYIKR ** :**** . **.* ** .** * : . .* . *: *. * .::. :** P43530 -----QIFSDYQSEVDIYNRIRNEL P06717 -----QIFSDYQSEVDIYNRIRDEL P01555 -----QIFSGYQSDIDTHNRIKDEL P13810 RLALTFFMSE--DDFIGVHGERDEL P43528 KFTLMTLLSINNDGFFSNNGGKDEL ::* . . : ::** Multiple sequence alignment of toxins that activate adenylate cyclase ___________________________________________________________________________ ___________________________________________________________________________ (II)CLUSTAL X (1.81) multiple sequence alignment (activate guanylate cyclase) P01559 MKKLMLAIFISVLSFPSFSQSTESLDSSKEKITLETKKCDVVKNNSEKKSENMNNT-FYC P01560 ------------------------------------------------------NT-FYC Q47185 MKKSILFIFLSVLSFSPFAQDAKPAGSSKEKITLESKKCNIVKKNNESSPESMNSS-NYC P07965 MKKSILFIFLSVLSFSPFAQDAKPVESSKEKITLESKKCNIAKKSNKSGPESMNSS-NYC P74977 MKKIILALVLMLFSFCTLGQETASMHLDDTLSAPIAAEINRKACDTQTPSPSEEND-DWC O50319 MKKIVFVLTLMLFSFGTLGQETASGQVGDVSSSTIATEVSEAECGTQSATTQGENDWDWC P07593 MKKIVFVLVLMLSSFGAFGQETVSGQFSDALSTPITAEVYKQACDPPLPPAEVSSD-WDC P22542 MKKNIAFLLASMFVFSIATNAYASTQSNKKDLCEHYRQIAKESCKKGFLGVRDGTA-GAC . * P01559 CELCCNPACAGCY P01560 CELCCYPACAGCN Q47185 CELCCNPACTGCY P07965 CELCCNPACTGCY P74977 CEVCCNPACAGC- O50319 CELCCNPACFGC- P07593 CDVCCNPACAGC- P22542 FGAQIMVAAKGC- *. ** Multiple sequence alignment of toxins that activate guanylate cyclase ____________________________________________________________________________ ____________________________________________________________________________ (III)CLUSTAL X (1.81) multiple sequence alignment (Macrophage cytotoxins) P55129 --MANSQLDRVKGLIDSLNQHTKSAAKSGAGALKNGLG-----------QVKQAGQKLIL P55131 MSTWSSMLADLKKRAEEAKRQAKKGYDVTKNGLQYGVSQAKLQALAAGKAVQKYGNKLVL P15377 --MSKITLSSLKSSLQQGLKNGKNKLNQAGTTLKNGLTQTG-------HSLQNGAKKLIL . * :* :. :: *. . *: *: ::: .:**:* P55129 YIPKDYQASTGSSLNDLVKAAEALGIEVHRSEKNGTALAKELFGTTEKLLGFSERGIALF P55131 VIPKEYDGSVGNGFFDLVKAAEELGIQVKYVNRNELEVAHKSLGTADQFLGLTERGLTLF P15377 YIPQGYDSGQGNGVQDLVKAANDLGIEVWREERSNLDIAKTSFDTTQKILGFTDRGIVLF **: *:.. *... ******: ***:* ::. :*: :.*::::**:::**:.** P55129 APQFDKLLNKNQKLSKSLGGSSEALGQRLNKTQTALSALQSFLGTAIAGMDLDSLLRRRR P55131 APQLDQFLQKHSKISNVVGSSTGDAVSKLAKSQTIISGIQSVLGTVLAGINLNEAIISGG P15377 APQLDNLLKKNPKIGNTLG-SASSISQNIGKANTVLGGIQSILGSVLSGVNLNELLQNKD ***:*::*:*: *:.: :* *: ..: *::* :..:**.**:.::*::*:. : P55129 NGEDVSGSELAKAGVDLAAQLVDNIASATGTVDAFAEQLGKL-AMPYLTLALSGLASKLN P55131 -----SELELAEAGVSLASELVSNIAKGTTTIDAFTTQIQNFGKLVENAKGLGGVGRQLQ P15377 P----NQLELAKAGLELTNELVGNIASSVQTVDAFAEQISKLGSHLQNVKGLGGLSNKLQ . ***:**:.*: :**.***... *:***: *: :: . .*.*:. :*: P55129 NLP--DLSLAGPGFDAVSGILSVVSASFILSNKDADAGTKAAAGIEISTKILGNIGKAVS P55131 NISGSALSKTGLGLDIISSLLSGVTASFALANKNASTSTKVAAGFELSNQVIGGITKAVS P15377 NLP--DLGKASLGLDIISGLLSGASAGLILADKEASTEKKAAAGVEFANQIIGNVTKAVS *:. *. :. *:* :*.:** .:*.: *::*:*.: .*.***.*::.:::*.: **** P55129 QYIIAQRVAAGLSTTAATGGLIGSVVALAISPLSFLNVADKFERAKQLEQYSERFKKFGY P55131 SYILAQRLAAGLSTTGPAAALIASSISLAISPLAFLRVADNFNRSKEIGEFAERFKKLGY P15377 SYILAQRVASGLSSTGPVAALIASTVALAVSPLSFLNVADKFKQADLIKSYSERFQKLGY .**:***:*:***:*.....**.* ::**:***:**.***:*:::. : .::***:*:** P55129 EGDSLLASFYRETGAIEAALTTINSVLSAASAGVGAAATGSLVGAPVAALVSAITGIISG P55131 DGDKLLSEFYHEAGTIDASITTISTALSAIAAGTAAASAGALVGAPITLLVTGITGLISG P15377 DGDRLLADFHRETGTIDASVTTINTALAAISGGVGAASAGSLVGAPVALLVAGVTGLITT :** **:.*::*:*:*:*::***.:.*:* :.*..**::*:*****:: **:.:**:*: P55129 ILDASKQAIFERVATKLANKIDEWEKKHGKNYFENGYDARHSAFLEDTFELLSQYNKEYS P55131 ILEFSKQPMLDHVASKIGNKIDEWEKKYGKNYFENGYDARHKAFLEDSFSLLSSFNKQYE P15377 ILEYSKQAMFEHVANKVHDRIVEWEKKHNKNYFEQGYDSRHLADLQDNMKFLINLNKELQ **: ***.::::**.*: ::* *****:.*****:***:** * *:*.:.:* . **: . P55129 VERVVAITQQRWDVNIGELAGITRKGADAKSGKAYVDFFEEGKLLEKDPDRFDKKVFDPL P55131 TERAVLITQQRWDEYIGELAGITGKGDKLSSGKAYVDYFQEGKLLEKKPDDFSKVVFDPT P15377 AERVVAITQQRWDNQIGDLAAISRRTDKISSGKAYVDAFEEGQHQSYDSS----VQLDNK .**.* ******* **:**.*: : . .******* *:**: . ... :* P55129 EGKIDLSSIN-KTTLLKFITPVFTAGEEIRERKQTGKYEYMTELFVKGKEKWVVTGVESH P55131 KGEIDISNSQ-TSTLLKFVTPLLTPGTESRERTQTGKYEYITKLVVKGKDKWVVNGVKDK P15377 NGIINISNTNRKTQSVLFRTPLLTPGEENRERIQEGKNSYITKLHIQRVDSWTVTDGDAS :* *::*. : .: : * **::*.* * *** * ** .*:*:* :: :.*.*.. . P55129 NAIYDYTNLIQLAID-----KKGEKRQVTIESHLGEKNDRIYLSSGSSIVYAGNGHDVAY P55131 GAVYDYTNLIQHAHISSSVARGEEYREVRLVSHLGNGNDKVFLAAGSAEIHAGEGHDVVY P15377 SSVDFTNVVQRIAVKFDDAGNIIESKDTKIIANLGAGNDNVFVGSSTTVIDGGDGHDRVH .:: . : : * . * ::. : ::** **.:::.:.:: : .*:*** .: P55129 YDKTDTGYLTFDGQSAQKAGEYIVTKELKADVKVLKEVVKTQDISVGKTCSEKLEYRDYE P55131 YDKTDTGLLVIDGTKATEQGRYSVTRELSGATKILREVIKNQKSAVGK-REETLEYRDYE P15377 YSRGEYGALVIDATAETEKGSYSVKRYVG-DSKALHETIATHQTNVGN-REEKIEYRRED *.: : * *.:*. : * * *.: : * *:*.: .:. **: .*.:*** : P55129 LSPFELGNGIRAKDELHSVEEIIGSNRKDKFFGSRFTDIFHGAKGDDEIYGNDGHDILYG P55131 LTQSGNSN-LKAHDELHSVEEIIGSNQRDEFKGSKFRDIFHGADGDDLLNGNDGDDILYG P15377 DR---FHTGYTVTDSLKSVEEIIGSQFNDIFKGSQFDDVFHGGNGVDTIDGNDGDDHLFG . . *.*:********: .* * **:* *:***..* * : ****.* *:* P55129 DDGNDVIHGGDGNDHLVGGNGNDRLIGGKGNNFLNGGDGDDELQVFEGQYNVLLGGAGND P55131 DKGNDELRGDNGNDQLYGGEGNDKLLGGNGNNYLSGGDGNDELQVLGNGFNVLRGGKGDD P15377 GAGDDVIDGGNGNNFLVGGTGNDIISGGKDN----------------------------- . *:* : *.:**: * ** *** : **:.* P55129 ILYGSDGTNLFDGGVGNDKIYGGLGKDIYRYSKEYGRHIIIEKG--GDDDTLLLSDLSFK P55131 KLYGSSGSDLLDGGEGNDYLEGGDGSDFYVYRSTSGNHTIYDQGKSSDLDKLYLSDFSFD P15377 --------------------------DIYVHKTGDGNDSITDSG---GQDKLAFSDVNLK *:* : . *.. * :.* . *.* :**..:. P55129 DVGFIRIGDDLLVNKRIGGTLYYHEDYNGNALTIKDWFKEGKEGQNNKIEKIVDKDGAYV P55131 RLLVEKVDDNLVLRS-------NESSHNNGVLTIKDWFKEGNK-YNHKIEQIVDKNGRKL P15377 DLTFKKVDSSLEIINQKGEKVRIGNWFLEDDLASTVANYKATN--DRKIEEIIGKGGERI : . ::...* : . . . . *: . :..: :.***:*:.*.* : P55129 LSQYLTELTAPGRGINYFNGLEEKLYYGEGYNALPQLRKDIEQIISSTG----------- P55131 TAENLGTYFKNAPKADNLLNYATKEDQNE--SNLSSLKTELSKIITNAGNFGVAKQGNTG P15377 TSEQVDKLIKEGNNQISAEALSKVVNDYNTSKDRQNVSNSLAKLISSVG----------- :: : . : . .: ..: ::*:..* P55129 ----ALTGEHGQVLVGA--------GGPLAYSNSPNSIPNAFSNYLTQSA P55131 INTAALNNEVNKIISSANTFATSQLGGSGMGTLPSTNVNSMMLGNLARAA P15377 ----SFTSSSDFRNNLG--------------TYVPSSIDVSNNIQLARAA ::... . . : ...: *:::* Multiple sequence alignment of macrophage cytotoxins ___________________________________________________________________________ ___________________________________________________________________________ (iV)CLUSTAL X (1.81) multiple sequence alignment(neurotoxin) P10844|nt -PVTINNFNYNDPIDNNNIIMMEPPFARGTGRYYKAFKITDRIWIIPERYTFGYKPEDFN Q60393|nt -PVNIKXFNYNDPINNDDIIMMEPFNDPGPGTYYKAFRIIDRIWIVPERFTYGFQPDQFN P10845|nt -PFVNKQFNYKDPVNGVDIAYIKIPN-VGQMQPVKAFKIHNKIWVIPERDTFTNPEEGDL Q45894|nt -PFVNKQFNYKDPVNGVDIAYIKIPN-AGQMQPVKAFKIHNKIWVIPERDTFTNPEEGDL Q00496|nt --PKINSFNYNDPVNDRTILYIKP---GGCQEFYKSFNIMKNIWIIPERNVIGTTPQ-DF P30995|nt --PTINSFNYNDPVNNRTILYIKP---GGCQQFYKSFNIMKNIWIIPERNVIGTIPQ-DF P30996|nt MPVAINSFNYNDPVNDDTILYMQIPYEEKSKKYYKAFEIMRNVWIIPERNTIGTNPS-DF P18640|nt -PITINNFNYSDPVDNKNILYLDTHLNTLANEPEKAFRITGNIWVIPDRFSRNSNPN--L P19321|nt MTWPVKDFNYSDPVNDNDILYLRIPQNKLITTPVKAFMITQNIWVIPERFSSDTNPS--L : ***.**::. * : *:* * .:*::*:* . P10844|nt KSSGIFNRDVCEYYDPDYLNTNDKKNIFLQTMIKLFNRIKSKPLGEKLLEMIINGIPYLG Q60393|nt ASTGVFSKDVYEYYDPTYLKTDAEKDKFLKTMIKLFNRINSKPSGQRLLDMIVDAIPYLG P10845|nt NPPPEAKQVPVSYYDSTYLSTDNEKDNYLKGVTKLFERIYSTDLGRMLLTSIVRGIPFWG Q45894|nt NPPPEAKQVPVSYYDSTYLSTDNEKDNYLKGVTKLFERIYSTDLGRMLLTSIVRGIPFWG Q00496|nt HPPTSLKNGDSSYYDPNYLQSDEEKDRFLKIVTKIFNRINNNLSGGILLEELSKANPYLG P30995|nt LPPTSLKNGDSSYYDPNYLQSDQEKDKFLKIVTKIFNRINDNLSGRILLEELSKANPYLG P30996|nt DPPASLKNGSSAYYDPNYLTTDAEKDRYLKTTIKLFKRINSNPAGKVLLQEISYAKPYLG P18640|nt NKPPRVTSPKSGYYDPNYLSTDSDKDPFLKEIIKLFKRINSREIGEELIYRLSTDIPFPG P19321|nt SKPPRPTSKYQSYYDPSYLSTDEQKDTFLKGIIKLFKRINERDIGKKLINYLVVGSPFMG . . ***. ** :: .*: :*: *:*:** . * *: : *: * P10844|nt DRRVPLEEFNTNIASVTVNKLISNPGEVERKKGIFANLIIFGPGPVLNENETIDIGIQNH Q60393|nt NASTPPDKFAANVANVSINKKIIQPGAEDQIKGLMTNLIIFGPGPVLSDNFTDSMIMNGH P10845|nt G--STIDTELKVIDTNCINVIQPD----GSYRSEELNLVIIGPSADIIQFECKSFGHEVL Q45894|nt G--STIDTELKVIDTNCINVIQPD----GSYRSEELNLVIIGPSADIIQFECKSFGHDVL Q00496|nt NDNTPDNQFH-IGDASAVEIKFSN----GSQDILLPNVIIMGAEPDLFETNSSNISLRNN P30995|nt NDNTPDGDFI-INDASAVPIQFSN----GSQSILLPNVIIMGAEPDLFETNSSNISLRNN P30996|nt NDHTPIDEFSPVTRTTSVNIKLST----NVESSMLLNLLVLGAGPDIFESCCYPVRKLID P18640|nt NNNTPINTFDFDVDFNSVDVKTRQGNNWVKTGSINPSVIITGPRENIIDPETSTFKLTNN P19321|nt DSSTPEDTFDFTRHTTNIAVEKFENGSWKVTNIITPSVLIFGPLPNILDYTASLTLQGQQ . . : .::: *. : : P10844|nt F-----ASREGFGGIMQMKFCPEYVSVFNNVQENKGASIFNRRGYFSDPALILMHELIHV Q60393|nt S-----PISEGFGARMMIRFCPSCLNVFNNVQENKDTSIFSRRAYFADPALTLMHELIHV P10845|nt N-----LTRNGYGSTQYIRFSPDFTFGFEESLEVDTNPLLGAGKFATDPAVTLAHELIHA Q45894|nt N-----LTRNGYGSTQYIRFSPDFTFGFEESLEVDTNPLLGAGKFATDPAVTLAHELIHA Q00496|nt ----YMPSNHRFGSIAIVTFSPEYSFRFNDNC---------MNEFIQDPALTLMHELIHS P30995|nt ----YMPSNHGFGSIAIVTFSPEYSFRFKDNS---------MNEFIQDPALTLMHELIHS P30996|nt PDVVYDPSNYGFGSINIVTFSPEYEYTFNDISGGHN---SSTESFIADPAISLAHELIHA P18640|nt T----FAAQEGFGALSIISISPRFMLTYSNATNDVGEGRFSKSEFCMDPILILMHELNHA P19321|nt S----NPSFEGFGTLSILKVAPEFLLTFSDVTSNQSSAVLGKSIFCMDPVIALMHELTHS :* : ..* :.: : ** : * *** * P10844|nt LHGLYGIKVDD-LPIVPNEKK-FFMQSTDAIQAEELYTFGGQDPSIITPSTDKSIYDKVL Q60393|nt LHGLYGIKISN-LPITPNTKE-FFMQHSDPVQAEELYTFGGHDPSVISPSTDMNIYNKAL P10845|nt GHRLYGIAINP-NRVFKVNTNAYYEMSGLEVSFEELRTFGGHDAKFIDSLQENEFRLYYY Q45894|nt EHRLYGIAINP-NRVFKVNTNAYYEMSGLEVSFEELRTFGGHDAKFIDSLQENEFRLYYY Q00496|nt LHGLYGAKGIT-TKYTITQKQNPLITNIRGTNIEEFLTFGGTDLNIITSAQSNDIYTNLL P30995|nt LHGLYGAKGIT-TKYTITQKQNPLITNIRGTNIEEFLTFGGTDLNIITSAQSNDIYTNLL P30996|nt LHGLYGARGVT-YEETIEVKQAPLMIAEKPIRLEEFLTFGGQDLNIITSAMKEKIYNNLL P18640|nt MHNLYGIAIPNDQTISSVTSNIFYSQYNVKLEYAEIYAFGGPTIDLIPKSARKYFEEKAL P19321|nt LHQLYGINIPSDKRIRPQVSEGFFSQDGPNVQFEELYTFGGLDVEIIPQIERSQLREKAL * *** .: *: :*** ..* : P10844|nt QNFRGIVDRLNKVLVCISD-PNININIYKNKFKDKYKFVEDSEGKYSIDVESFDKLYKSL Q60393|nt QNFQDIANRLN-IVSSAQG-SGIDISLYKQIYKNKYDFVEDPNGKYSVDKDKFDKLYKAL P10845|nt NKFKDIASTLNKAKSIVG--TTASLQYMKNVFKEKYLLSEDTSGKFSVDKLKFDKLYKML Q45894|nt NKFKDVASTLNKAKSIIG--TTASLQYMKNVFKEKYLLSEDTSGKFSVDKLKFDKLYKML Q00496|nt ADYKKIASKLSKVQVSN---PLLNP--YKDVFEAKYGLDKDASGIYSVNINKFNDIFKKL P30995|nt ADYKKIASKLSKVQVSN---PLLNP--YKDVFEAKYGLDKDASGIYSVNINKFNDIFKKL P30996|nt ANYEKIATRLSEVNSAP---PEYDINEYKDYFQWKYGLDKNADGSYTVNENKFNEIYKKL P18640|nt DYYRSIAKRLNSITTANPSSFNKYIGEYKQKLIRKYRFVVESSGEVTVNRNKFVELYNEL P19321|nt GHYKDIAKRLNNINKTIPSSWISNIDKYKKIFSEKYNFDKDNTGNFVVNIDKFNSLYSDL :. :. *. *. ** : : * :: .* .::. * P10844|nt MFGFTETNIAENYKIKTRASYFSDSLPPVKIKNLLDNEIYTIEEGFNISDKDMEKEYRGQ Q60393|nt MFGFTETNLAGEYGIKTRYSYFSEYLPPIKTEKLLDNTIYTQNEGFNIASKNLKTEFNGQ P10845|nt TEIYTEDNFVKFFKVLNRKTYLNFDKAVFKIN-IVPKVNYTIYDGFNLRNTNLAANFNGQ Q45894|nt TEIYTEDNFVNFFKVINRKTYLNFDKAVFRIN-IVPDENYTIKDGFNLKGANLSTNFNGQ Q00496|nt YS-FTEFDLRTKFQVKCRQTYIGQYKYFKLSN-LLNDSIYNISEGYNIN--NLKVNFRGQ P30995|nt YS-FTEFDLATKFQVKCRQTYIGQYKYFKLSN-LLNDSIYNISEGYNIN--NLKVNFRGQ P30996|nt YS-FTESDLANKFKVKCRNTYFIKYEFLKVPN-LLDDDIYTVSEGFNIG--NLAVNNRGQ P18640|nt TQIFTEFNYAKIYNVQNRKIYLSNVYTPVTAN-ILDDNVYDIQNGFNIPKSNLNVLFMGQ P19321|nt TNVMSEVVYSSQYNVKNRTHYFSRHYLPVFAN-ILDDNIYTIRDGFNLTNKGFNIENSGQ :* : : * *: : :: . * :*:*: .: ** P10844|nt NKAINKQAYEEISKEH-----------LAVYKIQMCKSVKAP-----GICIDVDNEDLFF Q60393|nt NKAVNKEAYEEISLEH-----------LVIYRIAMCKPVMYKNTGKSEQCIIVNNEDLFF P10845|nt NTEINNMNFTKLKNFTGLFEFYKLLCVRGIITSKTKSLDKGYNKALNDLCIKVNNWDLFF Q45894|nt NTEINSRNFTRLKNFTGLFEFYKLLCVRGIIPFKTKSLDEGYNKALNDLCIKVNNWDLFF Q00496|nt NANLNPRIITPITGRG---------LVKKIIRFCKNIVSVKGIRKS--ICIEINNGELFF P30995|nt NANLNPRIITPITGRG---------LVKKIIRFCKNIVSVKGIRKS--ICIEINNGELFF P30996|nt SIKLNPKIIDSIPDKG---------LVEKIVKFCKSVIPRKGTKAPPRLCIRVNNSELFF P18640|nt NLSRNPALRKVNPENMLY--------LFTKFCHKAIDGRSLYNKTLDCRELLVKNTDLPF P19321|nt NIERNPALQKLSSESVVD--------LFTKVCLRLTK-----NSRDDSTCIKVKNNRLPY . * : :.* * : P10844|nt IADKNSFSDDLSKNERIEYNTQSNYIENDFPINELILDTDLISKIELPSENTESLTDFN- Q60393|nt IANKDSFSKDLAKAETIAYNTQNNTIENNFSIDQLILDNDLSSGIDLPNENTEPFTNFDD P10845|nt SPSEDNFTN-DLNKGEEITSDTNIEAAEENISLDLIQQYYLTFNFDNEPENISIENLSSD Q45894|nt SPSEDNFTN-DLDKVEEITADTNIEAAEENISLDLIQQYYLTFDFDNEPENISIENLSSD Q00496|nt VASENSYNDDNINTPKEIDDTVTSNNNYENDLDQVILNFNSESAPGLSDEKLNLTIQNDA P30995|nt VASENSYNDDNINTPKEIDDTVTSNNNYENDLDQVILNFNSESAPGLSDEKLNLTIQNDA P30996|nt VASESSYNENDINTPKEIDDTTNLNNNYRNNLDEVILDYNSQTIPQISNRTLNTLVQDNS P18640|nt IGDISDVKTDIFLRKDINEETEVIYYPDNVSVDQVILS-KNTSEHGQLDLLYPSIDSESE P19321|nt VADKDSISQEIFENKIITDETNVQNYSDKFSLDESILDGQVPINPEIVDPLLPNVNMEPL . .. . : * . P10844|nt VDVPVYEKQ-----PAIKKIFTDENTIFQYLYSQTFPLDIRDISLTSSFDDALLFSNKVY Q60393|nt IDIPVYIKQ-----SALKKIFVDGDSLFEYLHAQTFPSNIENLQLTNSLNDALRNNNKVY P10845|nt IIGQLELMPNIERFPNGKKYELDKYTMFHYLRAQEFEHGKSRIALTNSVNEALLNPSRVY Q45894|nt IIGQLEPMPNIERFPNGKKYELDKYTMFHYLRAQEFEHGDSRIILTNSAEEALLKPNVAY Q00496|nt YIPKYDSNG----TSDIEQHDVNELNVFFYLDAQKVPEGENNVNLTSSIDTALLEQPKIY P30995|nt YIPKYDSNG----TSDIEQHDVNELNVFFYLDAQKVPEGENNVNLTSSIDTALLEQPKIY P30996|nt YVPRYDSNG----TSEIEEYDVVDFNVFFYLHAQKVPEGETNISLTSSIDTALLEESKD- P18640|nt ILPGENQVFY-----DNRTQNVDYLNSYYYLESQKLSDNVEDFTFTRSIEEALDNSAKVY P19321|nt NLPGEEIVFY-----DDITKYVDYLNSYYYLESQKLSNNVENITLTTSVEEALGYSNKIY . : ** :* . . . :* * : ** P10844|nt SFFSMDYIKTANKVVEAGLFAGWVKQIVNDFVIEANKSNTMDKIADISLIVPYIGLALNV Q60393|nt TFFSTNLVEKANTVVGASLFVNWVKGVIDDFTSESTQKSTIDKVSDVSIIIPYIGPALNV P10845|nt TFFSSDYVKKVNKATEAAMFLGWVEQLVYDFTDETSEVSTTDKIADITIIIPYIGPALNI Q45894|nt TFFSSKYVKKINKAVEAFMFLNWAEELVYDFTDETNEVTTMDKIADITIIVPYIGPALNI Q00496|nt TFFSSEFINNVNKPVQAALFVSWIQQVLVDFTTEANQKSTVDKIADISIVVPYIGLALNI P30995|nt TFFSSEFINNVNKPVQAALFVGWIQQVLVDFTTEANQKSTVDKIADISIVVPYIGLALNI P30996|nt IFFSSEFIDTINKPVNAALFIDWISKVIRDFTTEATQKSTVDKIADISLIVPYVGLALNI P18640|nt TYFP-TLANKVNAGVQGGLFLMWANDVVEDFTTNILRKDTLDKISDVSAIIPYIGPALNI P19321|nt TFLP-SLAEKVNKGVQAGLFLNWANEVVEDFTTNIMKKDTLDKISDVSVIIPYIGPALNI ::. .. * . . :* * . :: **. : . * **::*:: ::**:* ***: P10844|nt GNETAKGNFENAFEIAGASILLEFIPELLIPVVGAFLLESYIDN---KNKIIKTIDNALT Q60393|nt GNETAKENFKNAFEIGGAAILMEFIPELIVPIVGFFTLESYVGN---KGHIIMTISNALK P10845|nt GNMLYKDDFVGALIFSGAVILLEFIPEIAIPVLGTFALVSYIAN---KVLTVQTIDNALS Q45894|nt GNMLSKGEFVEAIIFTGVVAMLEFIPEYALPVFGTFAIVSYIAN---KVLTVQTINNALS Q00496|nt GNEAQKGNFKDALELLGAGILLEFEPELLIPTILVFTIKSFLGSSDNKNKVIKAINNALK P30995|nt GNEAQKGNFKDALELLGAGILLEFEPELLIPTILVFTIKSFLGSSDNKNKVIKAINNALK P30996|nt IIEAEKGNFEEAFELLGVGILLEFVPELTIPVILVFTIKSYIDSYENKNKAIKAINNSLI P18640|nt SNSVRRGNFTEAFAVTGVTILLEAFPEFTIPALGAFVIYSKVQE---RNEIIKTIDNCLE P19321|nt GNSALRGNFNQAFATAGVAFLLEGFPEFTIPALGVFTFYSSIQE---REKIIKTIENCLE : :* *: *. ::* ** :* . * : * : . : : :*.*.* P10844|nt KRNEKWSDMYGLIVAQWLSTVNTQFYTIKEGMYKALNYQAQALEEIIKYRYNIYSEKEKS Q60393|nt KRDQKWTDMYGLIVSQWLSTVNTQFYTIKERMYNALNNQSQAIEKIIEDQYNRYSEEDKM P10845|nt KRNEKWDEVYKYIVTNWLAKVNTQIDLIRKKMKEALENQAEATKAIINYQYNQYTEEEK- Q45894|nt KRNEKWDEVYKYTVTNWLAKVNTQIDLIREKMKKALENQAEATKAIINYQYNQYTEEEK- Q00496|nt ERDEKWKEVYSFIVSNWMTKINTQFNKRKEQMYQALQNQVNAIKTIIESKYNSYTLEEK- P30995|nt ERDEKWKEVYSFIVSNWMTKINTQFNKRKEQMYQALQNQVNALKAIIESKYNSYTLEEK- P30996|nt EREAKWKEIYSWIVSNWLTRINTQFNKRKEQMYQALQNQVDAIKTAIEYKYNNYTSDEK- P18640|nt QRIKRWKDSYEWMMGTWLSRIITQFNNISYQMYDSLNYQAGAIKAKIDLEYKKYSGSDK- P19321|nt QRVKRWKDSYQWMVSNWLSRITTQFNHINYQMYDSLSYQADAIKAKIDLEYKKYSGSDK- :* :* : * : *:: : **: * .:*. * * : *. .*: *: .:* P10844|nt NIN-----IDFNDINSKLNEGINQAIDNINNFINGCSVSYLMKKMIPLAVEKLLDFDNTL Q60393|nt NIN-----IDFNDIDFKLNQSINLAINNIDDFINQCSISYLMNRMIPLAVKKLKDFDDNL P10845|nt --NNIN--FNIDDLSSKLNESINKAMININKFLNQCSVSYLMNSMIPYGVKRLEDFDASL Q45894|nt --NNIN--FNIDDLSSKLNESINSAMININKFLDQCSVSYLMNSMIPYAVKRLKDFDASV Q00496|nt --NELTNKYDIKQIENELNQKVSIAMNNIDRFLTESSISYLMKIINEVKINKLREYDENV P30995|nt --NELTNKYDIEQIENELNQKVSIAMNNIDRFLTESSISYLMKLINEVKINKLREYDENV P30996|nt --NRLESEYNINNIEEELNKKVSLAMKNIERFMTESSISYLMKLINEAKVGKLKKYDNHV P18640|nt ----ENIKSQVENLKNSLDVKISEAMNNINKFIRECSVTYLFKNMLPKVIDELNEFDRNT P19321|nt ----ENIKSQVENLKNSLDVKISEAMNNINKFIRECSVTYLFKNMLPKVIDELNKFDLRT :..::. .*: :. *: **: *: .*::**:: : : .* .:* P10844|nt KKNLLNYIDENKLYLIGSAEYEKSKVNKYLKTIMPFDLSIYTNDTILIEMFNKYNSEILN Q60393|nt KRDLLEYIDTNELYLLDEVNILKSKVNRHLKDSIPFDLSLYTKDTILIQVFNNYISNISS P10845|nt KDALLKYIYDNRGTLIGQVDRLKDKVNNTLSTDIPFQLSKYVDNQRLLSTFTEYIKNIIN Q45894|nt RDVLLKYIYDNRGTLVLQVDRLKDEVNNTLSADIPFQLSKYVDNKKLLSTFTEYIKNIVN Q00496|nt KTYLLNYIIQHGSILGESQQELNSMVTDTLNNSIPFKLSSYTDDKILISYFNKFFKRIKS P30995|nt KTYLLDYIIKHGSILGESQQELNSMVIDTLNNSIPFKLSSYTDDKILISYFNKFFKRIKS P30996|nt KSDLLNYILDHRSILGEQTNELSDLVTSTLNSSIPFELSSYTNDKILIIYFNRLYKKIKD P18640|nt KAKLINLIDSHNIILVGEVDKLKAKVNNSFQNTIPFNIFSYTNNSLLKDIINEYFNNIND P19321|nt KTELINLIDSHNIILVGEVDRLKAKVNESFENTMPFNIFSYTNNSLLKDIINEYFNSIND : *:. * : * . : . * :. :**.: *..: * :.. . * . P10844|nt NIILNLRYKDNNLIDLSGYGAKVEVYDGVELNDKN--QFKLTSSANS--KIRVTQNQNII Q60393|nt NAILSLSYRGGRLIDSSGYGATMNVGSDVIFNDIGNGQFKLNNSENS--NITAHQSKFVV P10845|nt TSILNLRYESNHLIDLSRYASKINIGSKVNFDPIDKNQIQLFNLESS--KIEVILKNAIV Q45894|nt TSILSIVYKKDDLIDLSRYGAKINIGDRVYYDSIDKNQIKLINLESS--TIEVILKNAIV Q00496|nt SSVLNMRYKNDKYVDTSGYDSNININGDVYKYPTNKNQFGIYNDKLS--EVNISQNDYII P30995|nt SSVLNMRYKNDKYVDTSGYDSNININGDVYKYPTNKNQFGIYNDKLS--EVNISQNDYII P30996|nt SSILDMRYENNKFIDISGYGSNISINGNVYIYSTNRNQFGIYNSRLS--EVNIAQNNDII P18640|nt SKILSLQNRKNTLVDTSGYNAEVSEEGDVQLNPIFPFDFKLGSSGEDRGKVIVTQNENIV P19321|nt SKILSLQNKKNALVDTSGYNAEVRVGDNVQLNTIYTNDFKLSSSGD---KIIVNLNNNIL . :*.: . . :* * * : : . * :: : . : .. :: P10844|nt FNSVFLDFSVSFWIRIPKYKNDGIQNYIHNEYTIINCMK-NNSGWKISIRGN---RIIWT Q60393|nt YDSMFDNFSINFWVRTPKYNNNDIQTYLQNEYTIISCIK-NDSGWKVSIKGN---RIIWT P10845|nt YNSMYENFSTSFWIRIP-KYFNSIS--LNNEYTIINCME-NNSGWKVSLNYG---EIIWT Q45894|nt YNSMYENFSTSFWIKIP-KYFSKIN--LNNEYTIINCIE-NNSGWKVSLNYG---EIIWT Q00496|nt YDNKYKNFSISFWVRIPNYDNKIVN--VNNEYTIINCMRDNNSGWKVSLNHN---EIIWT P30995|nt YDNKYKNFSISFWVRIPNYDNKIVN--VNNEYTIINCMRDNNSGWKVSLNHN---EIIWT P30996|nt YNSRYQNFSISFWVRIP-KHYKPMN--HNREYTIINCMGNNNSGWKISLRTVRDCEIIWT P18640|nt YNSMYESFSISFWIRINKWVSNLP------GYTIIDSVK-NNSGWSIGIISN---FLVFT P19321|nt YSAIYENSSVSFWIKISKDLTNSHN-----EYTIINSIE-QNSGWKLCIRNG---NIEWI :. : . * .**:: . ****..: ::***.: : : : P10844|nt LIDINGKTKSVFFEYNIREDISEYINRWFFVTITNN-LNNAKIYINGKLESNTDIKDIRE Q60393|nt LIDVNAKSKSIFFEYSIKDNISDYINKWFSITITNDRLGNANIYINGSLKKSEKILNLDR P10845|nt LQDTQEIKQRVVFKYSQMINISDYINRWIFVTITNNRLNNSKIYINGRLIDQKPISNLGN Q45894|nt LQDNKQNIQRVVFKYSQMVNISDYINRWIFVTITNNRLTKSKIYINGRLIDQKPISNLGN Q00496|nt FEDNRGINQKLAFNYGNANGISDYINKWIFVTITNDRLGDSKLYINGNLIDQKSILNLGN P30995|nt LQDNSGINQKLAFNYGNANGISDYINKWIFVTITNDRLGDSKLYINGNLIDKKSILNLGN P30996|nt LQDTSGNKENLIFRYEELNRISNYINKWIFVTITNNRLGNSRIYINGNLIVEKSISNLGD P18640|nt LKQNEDSEQSINFSYDISNNAPGYN-KWFFVTVTNNMMGNMKIYINGKLIDTIKVKELTG P19321|nt LQDVNRKYKSLIFDYSESLSHTGYTNKWFFVTITNNIMGYMKLYINGELKQSQKIEDLDE : : : : * * . * :*: :*:**: : .:**** * : :: P10844|nt VIANGEIIFKLDGDIDRTQ--------FIWMKYFSIFNTELSQSNIEERYKIQSYSEYLK Q60393|nt INSSNDIDFKLINCTDTTK--------FVWIKDFNIFGRELNATEVSSLYWIQSSTNTLK P10845|nt IHASNNIMFKLDGCRDTHR--------YIWIKYFNLFDKELNEKEIKDLYDNQSNSGILK Q45894|nt IHASNKIMFKLDGCRDPRR--------YIMIKYFNLFDKELNEKEIKDLYDSQSNSGILK Q00496|nt IHVSDNILFKIVNCSYTR---------YIGIRYFNIFDKELDETEIQTLYSNEPNTNILK P30995|nt IHVSDNILFKIVNCSYTR---------YIGIRYFNIFDKELDETEIQTLYNNEPNANILK P30996|nt IHVSDNILFKIVGCDDET---------YVGIRYFKVFNTELDKTEIETLYSNEPDPSILK P18640|nt INFSKTITFEINKIPDTGLITSDSDNINMWIRDFYIFAKELDGKDINILFNSLQYTNVVK P19321|nt VKLDKTIVFGIDENIDE--------NQMLWIRDFNIFSKELSNEDINIVYEGQILRNVIK : . * * : : :: * :* **. ::. : :* P10844|nt DFWGNPLMYNKEYYMFNAGNKNSYIKLKKDSPVGEILTRS--KYNQNSKYINYRDLYIGE Q60393|nt DFWGNPLRYDTQYYLFNQGMQNIYIKYFSKASMGETAPRT--NFN--NAAINYQNLYLGL P10845|nt DFWGDYLQYDKPYYMLNLYDPNKYVDVNNVGIRGYMYLKGPRGSVMTTNIYLNSSLYRGT Q45894|nt DFWGNYLQYDKPYYMLNLFDPNKYVDVNNIGIRGYMYLKGPRGSVVTTNIYLNSTLYEGT Q00496|nt DFWGNYLLYDKEYYLLNVLKPNNFIDRRKDSTLSINNIR--------STILLANRLYSGI P30995|nt DFWGNYLLYDKEYYLLNVLKPNNFINRRTDSTLSINNIR--------STILLANRLYSGI P30996|nt NYWGNYLLYNKKYYLFNLLRKDKYITLNSG-ILNINQQRG----VTEGSVFLNYKLYEGV P18640|nt DYWGNDLRYNKEYYMVNIDYLNRYMYANSRQIVFNTRRNN----------NDFNEGYKII P19321|nt DYWGNPLKFDTEYYIINDNYIDRYIAPESNVLVLVQYPDR----------SKLYTGNPIT ::**: * ::. **:.* : :: . P10844|nt KFIIRRKSNSQSIN-DDIVRKEDYIYLDFFNLN-QEWRVYTYKYFKKEEEKLFLAPISDS Q60393|nt RFIIKKASNSRNINNDNIVREGDYIYLNIDNISDESYRVYVLVNSKEIQTQLFLAPINDD P10845|nt KFIIKKYAS---GNKDNIVRNNDRVYINVVVKNKEYR-LATNASQAGVEKILSALEIPDV Q45894|nt KFIIKKYAS---GNEDNIVRNNDRVYINVVVKNKEYR-LATNASQAGVEKILSALEIPDV Q00496|nt KVKIQRVN--NSSTNDNLVRKNDQVYINFVASKTHLFPLYADTATTNKEKTIKISSSGNR P30995|nt KVKIQRVN--NSSTNDNLVRKNDQVYINFVASKTHLLPLYADTATTNKEKTIKISSSGNR P30996|nt EVIIRKNGPIDISNTDNFVRKNDLAYINVVDRGVEYR-LYADTKSE-KEKIIRTSNLNDS P18640|nt IKRIRGNTNDTRVRGGDILYFDMTINNKAYNLFMKNETMYADNHSTEDIYAIGLREQTKD P19321|nt IKSVSDKNPYSRILNGDNIILHMLYNSRKYMIIRDTDTIYATQGGECSQNCVYALKLQSN : .: : . : . : . P10844|nt DEFYNTIQIKEYDEQ-PTYSCQLLFKKDEESTDEIGLIGIHRFYES-GIVFEEYKDYFCI Q60393|nt PTFYDVLQIKKYYEK-TTYNCQILCEKD---TKTFGLFGIGKFVKDYGYVWDTYDNYFCI P10845|nt GNLSQVVVMKSKNDQGITNKCKMNLQDN--NGNDIGFIGFHQFNNI---------AKLVA Q45894|nt GNLSQVVVMKSKDDQGIRNKCKMNLQDN--NGNDIGFIGFHLYDNI---------AKLVA Q00496|nt --FNQVVVMNSVG------NCTMNFKNN--NGNNIGLLGFKADT-------------VVA P30995|nt --FNQVVVMNSVG------NCTMNFKNN--NGNNIGLLGFKADT-------------VVA P30996|nt --LGQIIVMDSIGN-----NCTMNFQNN--NGSNIGLLGFHSNN-------------LVA P18640|nt INDN--IIFQIQPMNNTYYYASQIFKSNFNGENISGICSIGTYRFR----LGGDWYRHNY P19321|nt LGNYGIGIFSIKNIVSKNKYCSQIFSS-FRENTMLLADIYKPWRFS----FKNAYT---- :. . .. P10844|nt SKWYLKEVKRKPYNLKLGCNWQFIPKDEGWTE--- Q60393|nt SQWYLRRISENINKLRLGCNWQFIPVDEGWTE--- P10845|nt SNWYNRQIERS--SRTLGCSWEFIPVDDGWGERPL Q45894|nt SNWYNRQVGKA--SRTFGCSWEFIPVDDGWGESSL Q00496|nt STWYYTHMRDH--TNSNGCFWNFISEEHGWQEK-- P30995|nt STWYYTHMRDN--TNSNGFFWNFISEEHGWQEK-- P30996|nt SSWYYNNIRRN--TSSNGCFWSSISKENGWKE--- P18640|nt LVPTVKQGNYASLLESTSTHWGFVPVSE------- P19321|nt ---PVAVTNYETKLLSTSSFWKFISRDPGWVE--- . * :. . Multiple sequence alignment of neurotoxins ___________________________________________________________________________ ___________________________________________________________________________ (V) CLUSTAL X (1.81) multiple sequence alignment(food poisioning toxins) P01553 -----MNKSRFISCVILIFALILVLFTPNVLAESQPDPT------------PDELHKASK P34071 -----MNKSRFISCVILIFALILVLFTPNVLAESQPDPT------------PDELHKSSE P23313 -----MYKRLFISRVILIFALILVISTPNVLAESQPDPM------------PDDLHKSSE P01552 -----MYKRLFISHVILIFALILVISTPNVLAESQPDPK------------PDELHKSSK O85382 --------MKKLSTVIIILILEIVFHNMNYVN-AQPDPK------------LDELNKVSD P0A0L2 --------MKKTAFTLLLFIALTLTTSPL-VNGSEKSEE------------INEKDLRKK P12993 --------MKKTAFILLLFIALTLTTSPL-VNGSEKSEE------------INEKDLRKK P20723 --------MKKFNILIALLFFTSLVISPLNVKANENIDS------------VKEKELHKK P0A0M0 -------MINKIKILFSFLALLLSFTSYAKAEDLHDKSE------------LTDLALANA P01558 MLSNNLNPMVFENAKEVFLISEDLKTPINITNSNSNLSDGLYVIDKGDGWILGEPSVVSS :: : . P01553 FT---GLMENMKVLYDDH-YVSATKVKSVDKFLAHDLIYNISDKKLKNYDKVKTELLNEG P34071 FT---GTMGNMKYLYDDH-YVSATKVMSVDKFLAHDLIYNISDKKLKNYDKVKTELLNED P23313 FT---GTMGNMKYLYDDH-YVSATKVKSVDKFLAHDLIYNISDKKLKNYDKVKTELLNED P01552 FT---GLMENMKVLYDDN-HVSAINVKSIDQFLYFDLIYSIKDTKLGNYDNVRVEFKNKD O85382 YKNNKGTMGNVMNLYTSP-PVEGRGVINSRQFLSHDLIFPIEYK---SYNEVKTELENTE P0A0L2 SELQGTALGNLKQIYYYNEKAKTENKESHDQFLQHTILFKGFFTDHSWYNDLLVDFDSKD P12993 SELQRNALSNLRQIYYYNEKAITENKESDDQFLENTLLFKGFFTGHPWYNDLLVDLGSKD P20723 SELSSTALNNMKHSYADKNPIIGENKSTGDQFLENTLLYKKFFTDLINFEDLLINFNSKE P0A0M0 YG-------------QYNHPFIKENIKSDEISGEKDLIFRNQGD---SGNDLRVKFATAD P01558 QILNPNETGTFSQSLTKSKEVSINVNFSVGFTSEFIQASVEYGFGITIGEQNTIERSVST . :. . P01553 LAKKYKDEVVDVYGSNYYVNCYFSSKD---------NVGKVTGGKTCMYGGITKHEGNHF P34071 LAKKYKDEVVDVYGSNYYVNCYFSSKD---------NVGKVTGGKTCMYGGITKHEGNHF P23313 LAKKYKDEVVDVYGSNYYVNCYFSSKD---------NVGKVTGGKTCMYGGITKHEGNHF P01552 LADKYKDKYVDVFGANYYYQCYFSKKTND------INSHQTDKRKTCMYGGVTEHNGNQL O85382 LANNYKDKKVDIFGVPYFYTCIIPKSE---------PDINQNFGGCCMYGGLTFNSS--- P0A0L2 IVDKYKGKKVDLYGAYYGYQCAGGTPN----------------KTACMYGGVTLHDNNRL P12993 ATNKYKGKKVDLYGAYYGYQCAGGTPN----------------KTACMYGGVTLHDNNRL P20723 MAQHFKSKNVDVYPIRYSINCYGGEID----------------RTACTYGGVTPHEGNKL P0A0M0 LAQKFKNKNVDIYGASFYYKCEKISEN----------------ISECLYGGTTLNSE-KL P01558 TAGPNEYVYYKVYATYRKYQAIRISHGNISDDGSIYKLTGIWLSKTSADSLGNIDQGSLI . : .:: . . . . .. P01553 DNGNLQNVLIRVYENKRNTISFEVQTDKKSVTAQELDIKARNFLINK----KNLYEFN-- P34071 DNGNLQNVLIRVYENKRNTISFEVQTDKKSVTAQELDIKARNFLINK----KNLYEFN-- P23313 DNGNLQNVLVRVYENKRNTISFEVQTDKKSVTAQELDIKARNFLINK----KNLYEFN-- P01552 D--KYRSITVRVFEDGKNLLSFDVQTNKKKVTAQELDYLTRHYLVKN----KKLYEFN-- O85382 ENERDKLITVQVTIDNRQSLGFTITTNKNMVTIQELDYKARHWLTKE----KKLYEFD-- P0A0L2 TEEKKVPINLWLDGKQNTVPLETVKTNKKNVTVQELDLQARRYLQEK----YNLYNSDVF P12993 TEEKKVPINLWIDGKQTTVPIDKVKTSKKEVTVQELDLQARHYLHGK----FGLYNSDSF P20723 KERKKIPINLWINGVQKEVSLDKVQTDKKNVTVQELDAQARRYLQKD----LKLYNNDTL P0A0M0 AQERVIGANVWVDGIQK--ETELIRTNKKNVTLQELDIKIRKILSDK----YKIYYKD-- P01558 ETGERCVLTVPSTDIEKEILDLAAATERLNLTDALNSNPAGNLYDWRSSNSYPWTQKLNL . : *.: :* . . P01553 SSPYETGYIKFIENNGNTFWYDMMPAPGDK-FDQSKYLMMYNDNKTVDSK-SVKIEVHLT P34071 SSPYETGYIKFIENNGNTFWYDMMPAPGDK-FDQSKYLMMYNDNKTVDSK-SVKIEVHLT P23313 SSPYETGYIKFIENNGNTFWYDMMPAPGDK-FDQSKYLMMYNDNKTVDSK-SVKIEVHLT P01552 NSPYETGYIKFIENE-NSFWYDMMPAPGDK-FDQSKYLMMYNDNKMVDSK-DVKIEVYLT O85382 GSAFESGYIKFTEKNNTSFWFDLFPKKELVPFVPYKFLNIYGDNKVVDSK-SIKMEVFLN P0A0L2 DGKVQRGLIVFHTSTEPSVNYDLFGAQGQY---SNTLLRIYRDNKTINSE-NMHIDIYLY P12993 GGKVQRGLIVFHSSEGSTVSYDLFDAQGQY---PDTLLRIYRDNKTINSE-NLHIDLYLY P20723 GGKIQRGKIEFDSSDGSKVSYDLFDVKGDF---PEKQLRIYSDNKTLSTE-HLHIDIYLY P0A0M0 -SEISKGLIEFDMKTPRDYSFDIYDLKGEN---DYEIDKIYEDNKTLKSDDISHIDVNLY P01558 HLTITATGQKYRILASKIVDFNIYSNNFNNLVKLEQSLGDGVKDHYVDISLDAGQYVLVM : ::: .:: :. . : : P01553 TKNG--------------- P34071 TKNG--------------- P23313 TKNG--------------- P01552 TKKK--------------- O85382 TH----------------- P0A0L2 TS----------------- P12993 TT----------------- P20723 EK----------------- P0A0M0 TKKKV-------------- P01558 KANSSYSGNYPYSILFQKF Multiple sequence alignment of food poisioning toxins _____________________________________________________________________________ _____________________________________________________________________________ (VI)CLUSTAL X (1.81) multiple sequence alignment(thiol-activating cytoxins) P19995 ------MIRFKKTKLIASIAMALCLFSQPVISFSKDITDKNQ------------------ P23564 --MKKKSNHLKGRKVLVSLLVSLQVFAFASISSAAPTEPND------------------- Q53957 MKDMSNKKIFKKYSRVAGLLTAALIVGNLVTANADSNKQNTANTETTTTNEQPKPESSEL Q54114 MKDMSNKKIFKKYSRVAGLLTAALIVGNLVTANADSNKQNTANTETTTTNEQPKPESSEL P21131 ---MSNKKTFKKYSRVAGLLTAALIIGNLVTANAESNKQNTASTETTTTNEQPKPESSEL P13128 ---MKKIMLVFITLILVSLPIAQQTEAKDASAFNKENSISSMAPPASPPASPKTP----- . :..: : . : . P19995 --------------------------------------------------SIDSGISSLS P23564 ---------------------------------------------------IDMGIAGLN Q53957 TTEKAGQKMDDMLNSNDMIKLAPKEMPLESAEKEEKKSEDNKKSEEDHTEEINDKIYSLN Q54114 TTEKAGQKMDDMLNSNDMIKLAPKEMPLESAEKEEKKSEDNKKSEEDHTEEINDKIYSLN P21131 TTEKAGQKTDDMLNSNDMIKLAPKEMPLESAEKEEKKSEDKKKSEEDHTEEINDKIYSLN P13128 -------------------------------------------IEKKHADEIDKYIQGLD *: * .*. P19995 YNRNEVLASNGDKIESFVPKEGKKTGNKFIVVERQKRSLTTSPVDISIIDSVNDRTYPGA P23564 YNRNEVLAIQGDQISSFVPKEGIQSNGKFIVVERDKKSLTTSPVDISIVDSITNRTYPGA Q53957 YNELEVLAKNGETIENFVPKEGVKKADKFIVIERKKKNINTTPVDISIIDSVTDRTYPAA Q54114 YNELEVLAKNGETIENFVPKEGVKKADKFIVIERKKKNINTTPVDISIIDSVTDRTYPAA P21131 YNELEVLAKNGETIENFVPKEGVKKADKFIVIERKKKNINTTPVDISIIDSVTDRTYPAA P13128 YNKNNVLVYHGDAVTNVPPRKGYKDGNEYIVVEKKKKSINQNNADIQVVNAISSLTYPGA **. :**. :*: : .. *::* : .::**:*:.*:.:. . .**.:::::.. ***.* P19995 LQLADKAFVENRPTILMVKRKPININIDLPGLKGE-NSIKVDDPTYGKVSGAIDELVSKW P23564 IQLANKDFADNQPSLVMAARKPLDISIDLPGLKNE-NTISVQNPNYGTVSSAIDQLVSTW Q53957 LQLANKGFTENKPDAVVTKRNPQKIHIDLPGMGDK-ATVEVNDPTYANVSTAIDNLVNQW Q54114 LQLANKGFTENKPDAVVTKRNPQKIHIDLPGMGDK-ATVEVNDPTYANVSTAIDNLVNQW P21131 LQLANKGFTENKPDAVVTKRNPQKIHIDLPGMGDK-ATVEVNDPTYANVSTAIDNLVNQW P13128 LVKANSELVENQPDVLPVKRDSLTLSIDLPGMTNQDNKIVVKNATKSNVNNAVNTLVERW : *:. :.:*:* : . *.. : *****: .: .: *.:.. ..*. *:: **. * P19995 NEKYSSTH-TLPARTQYSESMVYSKSQISSALNVNAKVLENSLGVDFNAVANNEKKVMIL P23564 GEKYSSTH-TLPARLQYAESMVYSQNQISSALNVNAKVLNGTLGIDFNAVANGEKKVMVA Q53957 HDNYSGGN-TLPARTQYTESMVYSKSQIEAALNVNSKILDGTLGIDFKSISKGEKKVMIA Q54114 HDNYSGGN-TLPARTQYTESMVYSKSQIEAALNVNSKILDGTLGIDFKSISKGEKKVMIA P21131 HDNYSGGN-TLPARTQYTESMVYSKSQIEAALNVNSKILDGTLGIDFKSISKGEKKVMIA P13128 NEKYAQAYPNVSAKIDYDDEMAYSESQLIAKFGTAFKAVNNSLNVNFGAISEGKMQEEVI ::*: .:.*: :* :.*.**:.*: : :.. * ::.:*.::* ::::.: : : P19995 AYKQIFYTVSADLPKNPSDLFDDSVTFNDLKQKGVSNEAPPLMVSNVAYGRTIYVKLETT P23564 AYKQIFYTVSAGLPNNPSDLFDDSVTFAELARKGVSNEAPPLMVSNVAYGRTIYVKLETT Q53957 AYKQIFYTVSANLPNNPADVFDKSVTFKELQAKGVSNEAPPLFVSNVAYGRTVFVKLETS Q54114 AYKQIFYTVSANLPNNPADVFDKSVTLKELQRKGVSNEAPPLFVSNVAYGRTVFVKLETS P21131 AYKQIFYTVSANLPNNPADVFDKSVTFKELQRKGVSNEAPPLFVSNVAYGRTVFVKLETS P13128 SFKQIYYNVNVNEPTRPSRFFGKAVTKEQLQALGVNAENPPAYISSVAYGRQVYLKLSTN ::***:*.*... *..*: .*..:** :* **. * ** :*.***** :::**.*. P19995 SSSKDVQAAFKALIKNTDIKNSQQYKDIYENSSFTAVVLGGDAQEHNKVVTKDFDEIRKV P23564 SKSNDVQTAFKLLLNNPSIQASGQYKDIYENSSFTAVVLGGDAQTHNQVVTKDFNVIQSV Q53957 SKSNDVEAAFSAALKGTDVKTNGKYSDILENSSFTAVVLGADAAEHNKVVTKDFDVIRNV Q54114 SKSNDVEAAFSAALKGTDVKTNGKYSDILENSSFTAVVLGGDAAEHNKVVTKDFDVIRNV P21131 SKSNDVEAAFSAALKGTDVKTNGKYSDILENSSFTAVVLGGDAAEHNKVVTKDFDVIRNV P13128 SHSTKVKAAFDAAVSGKSVSGDVELTNIIKNSSFKAVIYGGSAKDEVQIIDGNLGDLRDI * *..*::**. :.. .:. . : .:* :****.**: *..* . ::: ::. ::.: P19995 IKDNATFSTKNPAYPISYTSVFLKDNSVAAVHNKTDYIETTSTEYSKGKINLDHSGAYVA P23564 IKDNAQFSSKNPAYPISYTSVFLKDNSIAAVHNNTEYIETKTTEYSKGKIKLDHSGAYVA Q53957 IKANATFSRKNPAYPISYTSVFLKNNKIAGVNNRSEYVETTSTEYTSGKINLSHQGAYVA Q54114 IKDNATFSRKNPAYPISYTSVFLKNNKIAGVNNRSEYVETTSTEYTSGKINLSHQGAYVA P21131 IKDNATFSRKNPAYPISYTSVFLKNNKIAGVNNRTEYVETTSTEYTSGKINLSHQGAYVA P13128 LKKGATFNRETPGVPIAYTTNFLKDNELAVIKNNSEYIETTSKAYTDGKINIDHSGGYVA :* .* *. :.*. **:**: ***:*.:* ::*.::*:**.:. *:.***::.*.*.*** P19995 QFEVAWDEVSYDKEGNEVLTHKTWDGNYQDKTAHYSTVIPLEANARNIRIKARECTGLAW P23564 QFEVYWDEFSYDADGQEIVTRKSWDGNWRDRSAHFSTEIPLPPNAKNIRIFARECTGLAW Q53957 QYEILWDEINYDDKGKEVITKRRWDNNWYSKTSPFSTVIPLGANSRNIRIMARECTGLAW Q54114 QYEILWDEINYDDKGKEVITKRRWDNNWYSKTSPFSTVIPLGANSRNIRIMARECTGLAW P21131 QYEILWDEINYDDKGKEVITKRRWDNNWYSKTSPFSTVIPLGANSRNIRIMARECTGLAW P13128 QFNISWDEVNYDPEGNEIVQHKNWSENNKSKLAHFTSSIYLPGNARNINVYAKECTGLAW *::: ***..** .*:*:: :: *. * .: : ::: * * *::**.: *:******* P19995 EWWRDVISEYDVPLTNNINVSIWGTTLYPGSSITYN---- P23564 EWWRTVVDEYNVPLASDINVSIWGTTLYPKSSITH----- Q53957 EWWRKVIDERDVKLSKEINVNISGSTLSPYGSITYK---- Q54114 EWWRKVIDERDVKLSKEINVNISGSTLSPYGSITYK---- P21131 EWWRKVIDERDVKLSKEINVNISGSTLSPYGSITYK---- P13128 EWWRTVIDDRNLPLVKNRNISIWGTTLYPKYSNKVDNPIE **** *:.: :: * .: *:.* *:** * * . Multiple sequence alignment of thiol-activating cytotoxins _____________________________________________________________________________ _____________________________________________________________________________ (VII)CLUSTAL X (1.81) multiple sequence alignment (vacuolaiting cytotoxin) Q48258 MEIQQTHRKINRPLVSLALVGALVSITP---------QQSHAAFFTTVIIPAIVGGIATG P55981 MEIQQTHRKINRPLVSLALVGALVSITP---------QQSHAAFFTTVIIPAIVGGIATG Q48245 MEIQQTHRKINRPLVSLALVGALVSITP---------QQSHAAFFTTVIIPAIVGGIATG Q48247 MEIQQTHRKINRPLVSLALVGALVSITP---------QQSHAAFFTTVIIPAIVGGIATG Q9ZKW5 MEIQQTHRKINRPLVSLVLAGALISAIP---------QESHAAFFTTVIIPAIVGGIATG Q48253 MEIQQTHRKINRPIISLALVGVLMGTELGANTPNDPIHSESRAFFTTVIIPAIVGGIATG *************::**.*.*.*:. :.. ****************** Q48258 AAVGTVSGLLGWGLKQAEEANKTPDKPDKVWRIQAGKGFNEFPNKEYDLYKSLLSSKIDG P55981 AAVGTVSGLLGWGLKQAEEANKTPDKPDKVWRIQAGKGFNEFPNKEYDLYRSLLSSKIDG Q48245 TAVGTVSGLLGWGLKQAEEANKTPDKPDKVWRIQAGKGFNEFPNKEYDLYKSLLSSKIDG Q48247 TAVGTVSGLLSWGLKQAEEANKTPDKPDKVWRIQAGKGFNEFPNKEYDLYRSLLSSKIDG Q9ZKW5 TAVGTVSGLLSWGLKQAEEANKTPDKPDKVWRIQAGKGFNEFPNKEYDLYKSLLSSKIDG Q48253 AAVGTVSGLLSWGLKQAEQANKAPDKPDKVWRIQAGRGFDNFPHKQYDLYKSLLSSKIDG :*********.*******:***:*************:**::**:*:****:********* Q48258 GWDWGNAARHYWVKDGQWNKLEVDMQNAVGTYNLSGLINFTGGDLDVNMQKATLRLGQFN P55981 GWDWGNAATHYWVKGGQWNKLEVDMKDAVGTYNLSGLRNFTGGDLDVNMQKATLRLGQFN Q48245 GWDWGNAATHYWIKGGQWNKLEVDMKDAVGTYKLSGLRNFTGGDLDVNMQKATLRLGQFN Q48247 GWDWGNAARHYWVKGGQQNKLEVDMKDAVGTYTLSGLRNFTGGDLDVNMQKATLRLGQFN Q9ZKW5 GWDWGNAARHYWVKGGQWNKLEVDMKDAVGTYKLSGLRNFTGGDLDVNMQKATLRLGQFN Q48253 GWDWGNAARHYWVKDGQWNKLEVDMQNAVGTYNLSGLINFTGGDLDVNMQKATLRLGQFN ******** ***:*.** *******::*****.**** ********************** Q48258 GNSFTSYKDSADRTTRVDFNAKNILIDNFLEINNRVGSGAGRKASSTVLTLQASEGITSR P55981 GNSFTSYKDSADRTTRVDFNAKNILIDNFLEINNRVGSGAGRKASSTVLTLQASEGITSS Q48245 GNSFTSYKDSADRTTRVDFNAKNILIDNFLEINNRVGSGAGRKASSTVLTLQASEGITSS Q48247 GNSFTSYKDSADRTTRVDFNAKNISIDNFVEINNRVGSGAGRKASSTVLTLQASEGITSD Q9ZKW5 GNSFTSYKDSADRTTRVNFNAKNISIDNFVEINNRVGSGAGRKASSTVLTLQASEGITSS Q48253 GNSFTSFKDGANRTTRVNFDAKNILIDNFVEINNRVGSGAGRKASSTVLTLKSSEKITSR ******:**.*:*****:*:**** ****:*********************::** *** Q48258 ENAEISLYDGATLNLASN---SVKLMGNVWMGRLQYVGAYLAPSYSTINTSKVTGEVNFN P55981 KNAEISLYDGATLNLASN---SVKLMGNVWMGRLQYVGAYLAPSYSTINTSKVTGEVNFN Q48245 KNAEISLYDGATLNLASN---SVKLNGNVWMGRLQYVGAYLAPSYSTINTSKVTGEVNFN Q48247 KNAEISLYDGATLNLASS---SVKLMGNVWMGRLQYVGAYLAPSYSTINTSKVTGEVNFN Q9ZKW5 KNAEISLYDGATLNLASN---SVKLNGNVWMGRLQYVGAYLAPSYSTINTSKVQGEVDFN Q48253 ENAEISLYDGATLNLVSSSNQSVDLYGKVWMGRLQYVGAYLAPSYSTIDTSKVQGEMNFR :**************.*. **.* *:********************:**** **::*. Q48258 HLTVGDHNAAQAGIIASNKTHIGTLDLWQSAGLNIIAPPEGGYKDKPNDKPSNT-----T P55981 HLTVGDHNAAQAGIIASNKTHIGTLDLWQSAGLNIIAPPEGGYKDKPKDKPSNT-----T Q48245 HLTVGDHNAAQAGIIASNKTHIGTLDLWQSAGLNIIAPPEGGYKDKPNNTPS-------- Q48247 HLTVGDKNAAQAGIIANKKTNIGTLDLWQSAGLNIIAPPEGGYKDKPNNTPSQSGAKNDK Q9ZKW5 HLTVGDQNAAQAGIIASNKTHIGTLDLWQSAGLNIIAPPEGGYKDKPNSTTSQS------ Q48253 HLAVGDQNAAQAGIIANKKTNIGTLDLWQSAGLSIITPPEGGYESKTKDNPQNN------ Q48258 QNNAKNDKQESSQNN-SNTQVINPPNSAQKTEIQPTQVIDGPFAGGKNTVVNINRINTNA P55981 QNNANNNQQNSAQNN-SNTQVINPPNSAQKTEIQPTQVIDGPFAGGKDTVVNIDRINTNA Q48245 QSGAKNDKQESSQNN-SNTQVINPPNSTQKTEVQPTQVIDGPFAGGKDTVVNIDRINTKA Q48247 NESAKNDKQESSQNN-SNTQVINPPNSAQKTEVQPTQVIDGPFAGGKDTVVNINRINTNA Q9ZKW5 --GTKNDKKEISQNNNSNTEVINPPNNTQKTETEPTQVIDGPFAGGKDTVVNIFHLNTKA Q48253 -----------------------PKNDAQKTEIQPTQVIDGPFAGGKDTVVNIFHLNTKA * *.:**** :*************:***** ::**:* Q48258 DGTIRVGGFKASLTTNAAHLHIGKGGINLSNQASGRSLLVENLTGNITVDGPLRVNNQVG P55981 DGTIKVGGYKASLTTNAAHLHIGKGGINLSNQASGRTLLVENLTGNITVDGPLRVNNQVG Q48245 DGTIKVGGFKASLTTNAAHLNIGKGGVNLSNQASGRTLLVENLTGNITVDGPLRVNNQVG Q48247 DGTIRVGGFKASLTTNAAHLHIGKGGVNLSNQASGRSLIVENLTGNITVDGPLRVNNQVG Q9ZKW5 DGTIKVGGFKASLTTNAAHLNIGKGGVNLSNQASGRTLLVENLTGNITVDGPLRVNNQVG Q48253 DGTLRAGGFKASLSTNAAHLHIGEGGVNLSNQASGRTLLVENLTGNITVEGTLRVNNQVG ***::.**:****:******:**:**:*********:*:**********:*.******** Q48258 GYALAGSSANFEFKAGTDTKNGTATFNNDISLGRFVNLKVDAHTANFKG----------- P55981 GYALAGSSANFEFKAGTDTKNGTATFNNDISLGRFVNLKVDAHTANFKG----------- Q48245 GYALAGSSANFEFKAGVDTKNGTATFNNDISLGRFVNLKVDAHTANFKG----------- Q48247 GYALAGSSANFEFKAGTDTKNGTATFNNDISLGRFVNLKVDAHTANFKG----------- Q9ZKW5 GYALAGSSANFEFKAGVDTKNGTATFNNDISLGRFVNLKVDAHTANFKG----------- Q48253 GAAIAGSSANFEFKAGEDTNNATATFNNDIHLGKAVNLRVDAHTANFNGNIYLGKSTNLR * *:************ **:*.******** **: ***:********:* Q48258 ------------IDTGNGGFN--TLDFSGVTNKVNINKLITASTNVAVKNFNINELVVKT P55981 ------------IDTGNGGFN--TLDFSGVTGKVNINKLITASTNVAVKNFNINELVVKT Q48245 ------------IDTGNGGFN--TLDFSGVTNKVNINKLITASTNVAVKNFNINELIVKT Q48247 ------------IDTGNGGFN--TLDFSGVTDKVNINKLITASTNVAVKNFNINELIVKT Q9ZKW5 ------------IDTGNGGFN--TLDFSGVTDKVNINKLITASTNVAVKNFNINELIVKT Q48253 VNGHTAHFKNIDATKSDNGLNTSTLDFSGVTDKVNINKLTTAATNVNIKNFDIKELVVTT ..:.*:* ********.******* **:*** :***:*:**:*.* Q48258 NGVSVGEYTHFSEDIGSQSRINTVRLETGTRSIYSGGVKFKGGEKLVINDFYYAPWNYFD P55981 NGVSVGEYTHFSEDIGSQSRINTVRLETGTRSIFSGGVKFKSGEKLVIDEFYYSPWNYFD Q48245 NGVSVGEYTHFSEDIGSQSRINTVRLETGTRSIFSGGVKFKSGEKLVIDEFYYSPWNYFD Q48247 NGISVGEYTHFSEDIGSQSRINTVRLETGTRSLFSGGVKFKGGEKLVIDEFYYSPWNYFD Q9ZKW5 NGISVGEYTHFSEDIGSQSRINTVRLETGTRSIFSGGVKFKSGEKLVINDFYYSPWNYFD Q48253 RVQSFGQYTIFGENIGDKSRIGVVSLQTGYSPAYSGGVTFKGGKKLVIDEIYHAPWNYFD . *.*:** *.*:**.:***..* *:** . :****.**.*:****:::*::****** Q48258 ARNIKNVEITNKLAFGPQGSPWGTAKLMFNNLTLGQNAVMDYSQFSNLTIQGDFVNNQGT P55981 ARNIKNVEITRKFASSTPENPWGTSKLMFNNLTLGQNAVMDYSQFSNLTIQGDFINNQGT Q48245 ARNIKNVEITRKFASSTPENPWGTSKLMFNNLTLGQNAVMDYSQFSNLTIQGDFINNQGT Q48247 ARNIKNVEITNKLAFGPQGSPWGTSKLMFNNLTLGQNAVMDYSQFSNLTIQGDFINNQGT Q9ZKW5 ARNVKNVEITRKFASSTPENPWGTSKLMFNNLTLGQNAVMDYSQFSNLTIQGDFINNQGT Q48253 ARNVTDVEINKRILFGAPGNIAGKTGLMFNNLTLNSNASMDYGKDLDLTIQGHFTNNQGT ***:.:***..:: .. . *.: ********..** ***.: :*****.* ***** Q48258 INYLVRGGQVATLNVGNAAAMFFSNNVDSATGFYQPLMKINSAQDLIKNKEHVLLKAKII P55981 INYLVRGGQVATLNVGNAAAMFFSNNVDSATGFYQPLMKINSAQDLIKNKEHVLLKAKII Q48245 INYLVRGGKVATLNVGNAAAMMFNNDIDSATGFYKPLIKINSAQDLIKNTEHVLLKAKII Q48247 INYLVRGGKVATLSVGNAAAMMFNNDIDSATGFYKPLIKINSAQDLIKNTEHVLLKAKII Q9ZKW5 INYLVRGGKVATLNVGNAAAMMFNNDIDSATGFYKPLIKINSAQDLIKNTEHVLLKAKII Q48253 MNLFVQDGRVATLNAGHQASMIFNNLVDSTTGFYKPLIKINNAQNLTKNKEHVLVKARNI :* :*:.*:****..*: *:*:*.* :**:****:**:***.**:* **.****:**: * Q48258 GYGNVSAG-----TDSIANVNLIEQFKERLALYNNNNRMDICVVR--NTDDIKACGTAIG P55981 GYGNVSLG-----TNSISNVNLIEQFKERLALYNNNNRMDICVVR--NTDDIKACGTAIG Q48245 GYGNVSTG-----TNGISNVNLEEQFKERLALYNNNNRMDTCVVR--NTDDIKACGMAIG Q48247 GYGNVSTG-----TNGISNVNLEEQFKERLALYNNNNRMDTCVVR--NTDDIKACGMAIG Q9ZKW5 GYGNVSTG-----TNGISNVNLEEQFKERLALYNNNNRMDTCVVR--NTDDIKACGMAIG Q48253 DYNLVGVQGASYDNISASNTNLQEQFKERLALYNNNNRMDTCVVRKDNLNDIKACGMAIG .*. *. . . :*.** ***************** **** * :****** *** Q48258 NQSMVNNPENYKYLEGKAWKNIGISKTANGSKISVHYLGNSTPTENGGNTTNLPTNTTNK P55981 NQSMVNNPDNYKYLIGKAWKNIGISKTANGSKISVYYLGNSTPTEKGGNTTNLPTNTTSN Q48245 NQSMVNNPDNYKYLIGKAWKNIGISKTANGSKISVYYLGNSTPTENGGNTTNLPTNTTNN Q48247 DQSMVNNPDNYKYLIGKAWKNIGISKTANGSKISVYYLGNSTPTENGGNTTNLPTNTTSN Q9ZKW5 NQSMVNNPDNYKYLIGKAWRNIGISKTANGSKISVYYLGNSTPTENGGNTTNLPTNTTNN Q48253 NQSMVNNPENYKYLEGKAWKNTGINKTANNTTIAVNLGNNSTPTNSTTDTTNLPTNTTNN :*******:***** ****:* **.****.:.*:* .*****:. :*********.: Q48258 VRFASYALIKNAPFARYSATPNLVAINQHDFGTIESVFELANRSNDIDTLYANSGAQGRD P55981 VRSANNALAQNAPFAQPSATPNLVAINQHDFGTIESVFELANRSKDIDTLYANSGAQGRD Q48245 ARFASYALIKNAPFAH-SATPNLVAINQHDFGTIESVFELANRSKDIDTLYANSGAQGRD Q48247 ARSANNALAQNAPFAQPSATPNLVAINQHDFGTIESVFELANRSKDIDTLYANSGAQGRD Q9ZKW5 AHSANYALVKNAPFAH-SATPNLVAINQHDFGTIESVFELANRSKDIDTLYTHSGAQGRD Q48253 ARFASYALIKNAPFAH-SATPNLVAINQHDFGTIESVFELANRSSDIDTLYANSGAQGRD .: *. ** :*****: ***************************.******::******* Q48258 LLQTLLIDSHDAGYARTMIDATSANEITKQLNTATTTLNNIASLEHKTSGLQTLSLSNAM P55981 LLQTLLIDSHDAGYARQMIDNTSTGEITKQLNAATTTLNNIASLEHKTSSLQTLSLSNAM Q48245 LLQTLLIDSHDAGYARTMIDATSANEITKQLNTATTTLNNIASLEHKTSSLQTLSLSNAM Q48247 LLQTLLIDSHDAGYARKMIDATSANEITKQLNTATTTLNNIASLEHKTSGLQTLSLSNAM Q9ZKW5 LLQTLLIDSHDAGYARQMIDNTSTGEITKQLNAATDALNNVASLEHKQSGLQTLSLSNAM Q48253 LLQTLLIDSHDAGYARTMIDATSANEITQQLNAATTTLNNIASLEHKTSGLQTLSLSNAM **************** *** **:.***:***:** :***:****** *.********** Q48258 ILNSRLVNLSRRHTNHIDSFAKRLQALKDQRFASLESAAEVLYQFAPKYEKPTNVWANAI P55981 ILNSRLVNLSRRHTNNIDSFAQRLQALKDQKFASLESAAEVLYQFAPKYEKPTNVWANAI Q48245 ILNSRLVNLSRRHTNNIDSFAKRLQALKDQRFASLESAAEVLYQFAPKYEKPTNVWANAI Q48247 ILNSRLVNLSRRHTNHIDSFAKRLQALKDQKFASLESAAEVLYQFAPKYEKPTNVWANAI Q9ZKW5 ILNSRLVNLSRKHTNHINSFAQRLQALKGQEFASLESAAEVLYQFAPKYEKPTNVWANAI Q48253 ILNSRLVNLSRKHTNHIDSFAKRLQALKDQRFASLESAAEVLYQFAPKYEKPTNVWANAI ***********:***:*:***:******.*.***************************** Q48258 GGTSLNSGGNASLYGTSAGVDAYLNGEVEAIVGGFGSYGYSSFSNQANSLNSGANNTNFG P55981 GGTSLNNGGNASLYGTSAGVDAYLNGEVEAIVGGFGSYGYSSFNNQANSLNSGANNTNFG Q48245 GGASLNNGGNASLYGTSAGVDAYLNGQVEAIVGGFGSYGYSSFNNQANSLNSGANNTNFG Q48247 GGTSLNNGSNASLYGTSAGVDAYLNGQVEAIVGGFGSYGYSSFNNRANSLNSGANNTNFG Q9ZKW5 GGASLNSGSNASLYGTSAGVDAFLNGNVEAIVGGFGSYGYSSFSNQANSLNSGANNANFG Q48253 GGTSLNNGSNASLYGTSAGVDAYLNGEVEAIVGGFGSYGYSSFSNQANSLNSGANNTNFG **:***.*.*************:***:****************.*:**********:*** Q48258 VYSRIFANQHEFDFEAQGALGSDQSSLNFKSALLRDLNQSYNYLAYSAATRASYGYDFAF P55981 VYSRIFANQHEFDFEAQGALGSDQSSLNFKSALLRDLNQSYNYLAYSAATRASYGYDFAF Q48245 VYSRIFANQHEFDFEAQGALGSDQSSLNFKSALLRDLNQSYNYLAYSAATRASYGYDFAF Q48247 VYSRIFANQHEFDFEAQGALGSDQSSLNFKSALLQDLNQSYHYLAYSAATRASYGYDFAF Q9ZKW5 VYSRFFANQHEFDFEAQGALGSDQSSLNFKSTLLQDLNQSYNYLAYSATARASYGYDFAF Q48253 VYSRIFANQHEFDFEAQGALGSDQSSLNFKSALLQDLNQSYHYLAYSATTRASYGYDFAF ****:**************************:**:******:******::********** Q48258 FRNALVLKPSVGVSYNHLGSTNFKSNSNQKVALKNGASSQHLFNASANVEARYYYGDTSY P55981 FRNALVLKPSVGVSYNHLGSTNFKSNSNQ-VALKNGSSSQHLFNASANVEARYYYGDTSY Q48245 FRNALVLKPSVGVSYNHLGSTNFKSNSTNKVALSNGSSSQHLFNASANVEARYYYGDTSY Q48247 FRNALVLKPSVGVSYNHLGSTNFKSNSTNQVALKNGSSSQHLFNASANVEARYYYGDTSY Q9ZKW5 FRNALVLKPSVGVSYNHLGSTNFKSNSQSQVALKNGASSQHLFNANANVEARYYYGDTSY Q48253 FRNALVLKPSVGVSYNHLGSTNFKSNSNQ-VALSNGSSSQHLFNANANVEARYYYGDTSY *************************** . ***.**:********.************** Q48258 FYMNAGVLQEFANFGSSNAVSLNTFKVNATRNPLNTHARVMMGGELKLAKEVFLNLGFVY P55981 FYMNAGVLQEFANFGSSNAVSLNTFKVNAAHNPLSTHARVMMGGELKLAKEVFLNLGFVY Q48245 FYMNAGVLQEFANFGSSNAVSLNTFKVNATRNPLNTHARVMMGGELKLAKEVFLNLGVVY Q48247 FYMNAGVLQEFAHVGSNNAASLNTFKVNAARNPLNTHARVMMGGELKLAKEVFLNLGVVY Q9ZKW5 FYLHAGVLQEFAHFGSNDVASLNTFKINAARSPLSTYARAMMGGELQLAKEVFLNLGVVY Q48253 FYMNAGVLQEFARFGSNNAVSLNTFKVNATRNPLNTHARVMMGGELQLAKEVFLNLGVVY **::********..**.:..******:**::.**.*:**.******:**********.** Q48258 LHNLISNIGHFASNLGMRYSF P55981 LHNLISNIGHFASNLGMRYSF Q48245 LHNLISNIGHFASNLGMRYSF Q48247 LHNLISNIGHFASNLGMRYSF Q9ZKW5 LHNLISNASHFASNLGMRYSF Q48253 LHNLISNASHFASNLGMRYSF ******* .************ Multiple sequence alignment of vacuolating cytotoxins ___________________________________________________________________________