The preliminary requirement for the stimulation of cytotoxic T cell response, a mechanism against viruses and certain tumors, is the processing and presentation of endogenous antigenic peptides by MHC-I molecules on the surface of the cell. Methods have been developed to classify and predict the binders and non-binders of MHC. Here we develop a SVM based method to predict the binding affinity of peptides to MHC-I. The method takes into consideration the amino acid sequence and the physio-chemical properties of proteins.