GDPbio: Genome based prediction of Diseases and Personal medicines using Bioinformatics

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Important Links
  1. Proteomic Contributions to Personalized Cancer Care
  2. FGFR2 Is a Breast Cancer Susceptibility Gene in Jewish and Arab Israeli Populations

    The following is the list of some important published articles related to Acute Lymphoblastic Leukemia study:
  3. Methylenetetrahydrofolate reductase gene polymorphisms and risk of acute lymphoblastic leukemia in children.
  4. Verification of the susceptibility loci on 7p12.2, 10q21.2, and 14q11.2 in precursor B-cell acute lymphoblastic leukemia of childhood.
  5. Multidrug resistance-associated protein 4 (MRP4) gene polymorphisms and treatment response in adult acute lymphoblastic leukemia.
  6. Germline genetic variation in an organic anion transporter polypeptide associated with methotrexate pharmacokinetics and clinical effects.
  7. TP53 R72P and MDM2 SNP309 polymorphisms in modification of childhood acute lymphoblastic leukemia susceptibility.
  8. An extensive analysis of the hereditary hemochromatosis gene HFE and neighboring histone genes: associations with childhood leukemia.
  9. Folate related gene polymorphisms and susceptibility to develop childhood acute lymphoblastic leukaemia.
  10. Strengths and weaknesses of gene association studies in childhood acute lymphoblastic leukemia.
  11. [Acute toxicity of high doses of methotrexate in treatment of ALL in children: a case study]
  12. Inherited susceptibility to pediatric acute lymphoblastic leukemia.
  13. Elevated mRNA level of hST6Gal I and hST3Gal V positively correlates with the high risk of pediatric acute leukemia.
  14. Loci on 7p12.2, 10q21.2 and 14q11.2 are associated with risk of childhood acute lymphoblastic leukemia.
  15. Germline genomic variants associated with childhood acute lymphoblastic leukemia.
  16. Genetic susceptibility to childhood acute lymphoblastic leukemia shows protection in Malay boys: results from the Malaysia-Singapore ALL Study Group.
  17. Role of the CYP2D6, EPHX1, MPO, and NQO1 genes in the susceptibility to acute lymphoblastic leukemia in Brazilian children.
  18. Genetic rearrangement MLL/AF4 is most frequent in children with acute lymphoblastic leukemias in Mexico City.
  19. DHFR 19-bp insertion/deletion polymorphism and MTHFR C677T in adult acute lymphoblastic leukaemia: is the risk reduction due to intracellular folate unbalancing?
  20. Role of GSTM1 (Present/Null) and GSTP1 (Ile105Val) polymorphisms in susceptibility to acute lymphoblastic leukemia among the South Indian population.
  21. Inheritance and clinical outcome in childhood acute lymphoblastic leukemia.
  22. A case-control study of childhood acute lymphoblastic leukaemia and polymorphisms in the TGF-beta and receptor genes.
  23. Polymorphisms of DNA repair genes and susceptibility to acute childhood lymphoblastic leukemia.
  24. Insights into the manifestations, outcomes, and mechanisms of leukemogenesis in Down syndrome.
  25. DNA repair gene XPD and XRCC1 polymorphisms and the risk of childhood acute lymphoblastic leukemia.
  26. Acquired variation outweighs inherited variation in whole genome analysis of methotrexate polyglutamate accumulation in leukemia.
  27. Polymorphisms in folate-related genes and risk of pediatric acute lymphoblastic leukemia.
  28. Risk-adapted stratification and treatment of childhood acute lymphoblastic leukaemia.
  29. Additional genetic risk factor for death in children with acute lymphoblastic leukemia: a common polymorphism of the MTHFR gene.
  30. Pharmacogenetics influence treatment efficacy in childhood acute lymphoblastic leukemia.
  31. [Genetic polymorphism in GST, NAT2, and MTRR and susceptibility to childhood acute leukemia]
  32. Do polymorphisms in ABC transporter genes influence risk of childhood acute lymphoblastic leukemia?
  33. Significance of genetic polymorphisms at multiple loci of CYP2E1 in the risk of development of childhood acute lymphoblastic leukemia.
  34. Methylenetetrahydrofolate reductase (MTHFR) C677T and thymidylate synthase promoter (TSER) polymorphisms in Indonesian children with and without leukemia.
  35. Risk factors for acute leukemia in children: a review.
  36. The potential effect of gender in combination with common genetic polymorphisms of drug-metabolizing enzymes on the risk of developing acute leukemia.
  37. Pharmacogenomics in cancer treatment defining genetic bases for inter-individual differences in responses to chemotherapy.
  38. Do polymorphisms of 5,10-methylenetetrahydrofolate reductase (MTHFR) gene affect the risk of childhood acute lymphoblastic leukemia?
  39. Genetic polymorphisms associated with adverse events and elimination of methotrexate in childhood acute lymphoblastic leukemia and malignant lymphoma.
  40. MTHFR polymorphisms and the development of acute leukemia: does it really matter?
  41. 5,10-Methylenetetrahydrofolate reductase polymorphisms and acute lymphoblastic leukemia risk: a meta-analysis.
  42. Promoter SNPs in G1/S checkpoint regulators and their impact on the susceptibility to childhood leukemia.
  43. [Genetic determinants of childhood leukemia]
  44. Polymorphisms in the MTHFR gene and their possible association with susceptibility to childhood acute lymphocytic leukemia in an Indian population.
  45. MTHFR and ALL risk: a challenge.
  46. [Genetic polymorphism and outcome in acute lymphoblastic leukaemia of childhood]
  47. Polymorphisms in ERCC1 and susceptibility to childhood acute lymphoblastic leukemia in a Chinese population.
  48. [Study on the relationship between polymorphisms of Cyp1A1, GSTM1, GSTT1 genes and the susceptibility to acute leukemia in the general population of Hunan province]
  49. Gene-expression profiles predict secondary leukaemia risk.
  50. Challenges identifying genetic determinants of pediatric cancers--the childhood leukemia experience.
  51. PMS2 mutations in childhood cancer.
  52. Role of CYP2D6, CYP1A1, CYP2E1, GSTT1, and GSTM1 genes in the susceptibility to acute leukemias.
  53. Effects of methylenetetrahydrofolate reductase and reduced folate carrier 1 polymorphisms on high-dose methotrexate-induced toxicities in children with acute lymphoblastic leukemia or lymphoma.
  54. Genetic polymorphisms and haplotypes of DNA repair genes in childhood acute lymphoblastic leukemia.
  55. Acute lymphoblastic leukemia in children with associated genetic conditions other than Down's syndrome. The AIEOP experience.
  56. ATM variants and predisposition to childhood T-lineage acute lymphoblastic leukaemia.
  57. Cyclin D1 gene polymorphism and susceptibility to childhood acute lymphoblastic leukemia in a Chinese population.
  58. MTHFR genetic polymorphisms and susceptibility to childhood acute lymphoblastic leukemia.
  59. Relation between genetic variants of the ataxia telangiectasia-mutated (ATM) gene, drug resistance, clinical outcome and predisposition to childhood T-lineage acute lymphoblastic leukaemia.
  60. Molecular genetics of acute lymphoblastic leukemia.
  61. Polymorphisms of drug-metabolizing enzymes and risk of childhood acute lymphoblastic leukemia.
  62. Polymorphisms of methylenetetrahydrofolate reductase (MTHFR) and susceptibility to pediatric acute lymphoblastic leukemia in a German study population.
  63. [Study on the correlation between acute lymphoblastic leukemia and HLA genes in southern China Han population.]
  64. DNA repair gene XRCC1 polymorphisms in childhood acute lymphoblastic leukemia.
  65. Cytochrome P4501A1 polymorphism is associated with susceptibility to acute lymphoblastic leukemia in adult Mexican patients.
  66. Genetic polymorphism of CYP1A1, CYP2D6, GSTM1 and GSTT1 and susceptibility to acute lymphoblastic leukaemia in Indian children.
  67. Genetic polymorphisms of CYP1A1, CYP2D6, GSTM1, and GSTT1 and susceptibility to acute lymphoblastic leukemia in Indian children.
  68. Susceptibility to cancer: why did this happen to my child?
  69. Functional C3435T polymorphism of MDR1 gene: an impact on genetic susceptibility and clinical outcome of childhood acute lymphoblastic leukemia.
  70. Genetic polymorphisms and susceptibility to childhood acute lymphoblastic leukemia.
  71. Glutathione S-transferase P1 genetic polymorphisms and susceptibility to childhood acute lymphoblastic leukaemia.
  72. Childhood acute lymphoblastic leukemia.
  73. The GSTM1 and GSTT1 genetic polymorphisms and susceptibility to acute lymphoblastic leukemia in children from north Portugal.
  74. Glutathione S-transferase genotypes, genetic susceptibility, and outcome of therapy in childhood acute lymphoblastic leukemia.
  75. Childhood acute lymphoblastic leukemia: genetic determinants of susceptibility and disease outcome.
  76. Childhood acute lymphoblastic leukaemia--current status and future perspectives.
  77. Role of NQO1, MPO and CYP2E1 genetic polymorphisms in the susceptibility to childhood acute lymphoblastic leukemia.
  78. Genetic studies in acute lymphoblastic leukemia.
  79. Genetic susceptibility to childhood acute lymphoblastic leukemia.
  80. The glutathione S-transferase mu polymorphism and susceptibility to acute lymphocytic leukemia.
  81. Parental smoking, CYP1A1 genetic polymorphisms and childhood leukemia
  82. Genetic polymorphisms of N-acetyltransferases 1 and 2 and gene-gene interaction in the susceptibility to childhood acute lymphoblastic leukemia.
  83. Risk of childhood leukemia associated with exposure to pesticides and with gene polymorphisms.
  84. Childhood leukemia and pesticides.
  85. Why is acute leukemia more common in males? A possible sex-determined risk linked to the ABO blood group genes.
  86. Genes and cancer.
  87. Susceptibility to childhood acute lymphoblastic leukemia: influence of CYP1A1, CYP2D6, GSTM1, and GSTT1 genetic polymorphisms.
  88. Biologic and cytogenetic characteristics of leukemia in infants.