Expertise:

Nuclear Receptors, Molecular Immunology, Cell Biology, Infectious Disease, Protein Science.

Profile:

Host-Pathogen Interaction (Mycobacterium tuberculosis, Mtb): We are investigating host lipid sensing nuclear receptor and pathogen lipids, contributing towards Mtb pathogenesis or clearance.
Molecular Immunology: We are using mice models of autoimmunity, allergy and inflammatory diseases to study differential expression and function of nuclear receptor in plasticity, polarization and activation of T cell, B cell, DCs and macrophage.
Metabolic Diseases: Molecular circuitry of neuron function, cancer biology, anemia and sepsis at the level of transcription factors. SMART and Switchable Therapeutics: Oral/bronchial protein vehicle from bromelain. Next generation switchable recombinant erythropoietin, Protein Nucleic Acid (PNA) Mimetics for anti-gene/-sense therapy towards Mtb.

Major Publications

• Chandra, V., Bhagyaraj, E., Nanduri, R., Ahuja, N., and Gupta, P. (2015) NR1D1 ameliorates Mycobacterium tuberculosis clearance through regulation of autophagy. Autophagy 11, 1987-1997.
• Chandra, V., Bhagyaraj, E., Parkesh, R., and Gupta, P. (2016) Transcription factors and cognate signalling cascades in the regulation of autophagy. Biol Rev Camb Philos Soc 91, 429-451.
• Bhagyaraj, E., Nanduri, R., Saini, A., Dkhar, H. K., Ahuja, N., Chandra, V., Mahajan, S., Kalra, R., Tiwari, D., Sharma, C., Janmeja, A. K., and Gupta, P. (2016) Human Xenobiotic Nuclear Receptor PXR Augments Mycobacterium tuberculosis Survival. J Immunol 197, 244-255.
• Dkhar, H. K., Nanduri, R., Mahajan, S., Dave, S., Saini, A., Somavarapu, A. K., Arora, A., Parkesh, R., Thakur, K. G., Mayilraj, S., and Gupta, P. (2014) Mycobacterium tuberculosis keto-mycolic acid and macrophage nuclear receptor TR4 modulate foamy biogenesis in granulomas: a case of a heterologous and noncanonical ligand-receptor pair. J Immunol 193, 295-305.
• Mahajan, S., Dkhar, H. K., Chandra, V., Dave, S., Nanduri, R., Janmeja, A. K., Agrewala, J. N., and Gupta, P. (2012) Mycobacterium tuberculosis modulates macrophage lipid-sensing nuclear receptors PPARgamma and TR4 for survival. J Immunol 188, 5593-5603.