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सी.एस.आई.आर - सूक्ष्‍मजीव प्रौद्योगिकी संस्‍थान विज्ञान एवं प्रौद्योगिकी मंत्रालय, भारत सरकार

CSIR - Institute of Microbial Technology

Ministry of Science & Technology, Govt. of India

अंग्रेजी वेबसाइट से डेटा रूपांतरण
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Home

The facility is well equipped with upstream and downstream processing units and various utilities for production of high value/ low volume and low volume/ high value products. It has been used in house for development of protein therapeutics (e.g., recombinant streptokinase and recombinant staphylokinase), enzymes (e.g., α-amylase, alkaline proteases, laccase, xylanase), bioactives (cerulomycin, antimicrobial peptides) and other chemicals/ biochemical (ethanol, pullulan, bacteriorhodopsin, sophrolipids) and offered to other academic and industrial clients for bioprocess optimization and scale up and production of therapeutic proteins for toxicology studies and clinical trials.

Media optimizationBioprocess optimization
Batch/Fed Batch fermentationFermentation
Scale upBioprocess Scale up
DCGI Certified Fermentation facilityDCGI Certifiable facility for Biopharmaceutical
Down stream processingDown Stream Processing


About US

Biochemical Engineering Research and Process Development Center (BERPDC), a fermentation facility, funded Jointly by DBT and Council of Scientific and Industrial Research (CSIR), was established in 1986 in the Institute of Microbial Technology (IMTECH) chandigarh. It is one of Indias largest and most sophisticated centers for research in technology development, process optimization and scale up in the field of biochemical engineering. The center is equipped with state of the art facilities to carry out cutting edge research in the area of fermentation technology and is backed by excellent analytical facilities. The fully computerized pilot plant, for complete scale up and optimization is among the best of its type in India.

The facility has been catering to the fermentation requirements of various users from the Industry and other research and development establishment. The main objective of our fermentation facilities are to do research and provide services to the biotechnology and pharmaceutical industries. This unit of IMTECH has developed and transferred technology on biochemical processes and biopharmaceuticals like natural streptokinase, recombinant streptokinase, recombinant staphylokinase, urokinase, thermotolerent yeast for alcohol production, alkaline protease and alpha amylase. Few of those technology have already been commercialized. At present fermentation scientist are working on new generation thrombolytics and technology platforms on high cell density bacterial and yeast fermentation, exopolysaccharides like pullulan, xanthum gum, bacteriorhodopsin and biosurfactants.



Facilities

  • Fermentation
  • Downstream Processing
  • Bioincubators (Including cGMP facility for biopharmaceuticals)




Fermentation


Lab Scale Fermenters

5L Fermenter

7.5 L Fermenter

15 L Fermenter


Pilot Scale Fermenters

150L Fermenter

500 L Fermenter

Utilities


Downstream Processing Facility


Lab Scale
Cell Disruption System
High pressure Homogenizer
Dyno Mill
Cell Separation System
Batch Centrifuge
Membrane Filteration System
Hollow fiber membrane
TFF : Micro, Ultra
Protein Purification
Chromotography system for protein purification.


Pilot Scale
Cell Disruption system
Continuous High pressure Homogenizer
Cell separation system
Continuous centrifuge
Membrane Filteration system
Microfiltration
Ultrafiltration
Protein Purification
Chromotography system for parameter optimization.


Bioincubators (Including cGMP facility for biopharmaceuticals)


Bioincubator I Bioincubator II Bioincubator III

Technologies Developed

Achievements

  • Transferred high efficient alcohol technology to McDowel &Co, Bangalore.
  • Transferred natural streptokinase to cadila Pharmaceuticals, Ahmedabad.
  • Transferred recombinant alkaline protease and alpha amylase to Celestial Labs, Hyderabad.
  • Transferred recombinant streptokinase production process to Shasun Drugs and chemicals, Chennai.
  • Transferred clot specific streptokinase CSSK, Nostrum Pharma USA.
  • Transferred PEGylated clot specific streptokinase to Nostrum Pharma USA
  • Transferred recombinant streptokinase technology to Epygen, Mumbai.


Technology under development

  • Microbial production of pullulan
  • Microbial production of sophorolipids
  • Colour shift protein film.

Industrial Collaboration

I. Industries We Served

  • Nostrum Pharmaceuticals
  • DSM, Netherlands.
  • McDowel & Co, Bangalore
  • Cadila Pharmaceuticals, Ahmedabad.
  • Biologicals Evans Limited, Hyderabad.
  • Shasun Drugs and chemicals, Chennai.
  • Strides Acrolabs, Bangalore
  • Kopran Drugs
  • Epygen Biotech, Mumbai
  • Symmetrix Biotech Pvt Ltd, Mumbai.
  • Backons Industries Ltd, Mohali.
  • Max-GB, Ropar
  • SPIC, Chennai.
  • Punjab Agro Industries Limited, Chandigarh.
  • Transgene Biotech, Hyderabad.
  • Dabur India Ltd, Ghaziabad.
  • Vam organics Ltd UP.
  • Bigtec, Bangalore
  • Celestial Labs Ltd, Hyderabad.
  • M/S Praneet Environ Tech, Chandigarh and others...

II. Ongoing Industrial Projects

  • Epygen Biotech
  • Excellex Biopolymers Pvt Ltd
Natural streptokinase from M/S Cadila Pharma Ltd Recombinant streptokinase from M/S Shasun chemicals and drugs

Jobs Undertaken

  • Strain Improvement
  • Feasibility studies of Fermentation process
  • Media and process Optimization
  • Fermentation scale up
  • Downstream Processing
  • Inhouse technology development
  • Teaching and Human resource development
  • Contract, Consultancy and Sponsored projects.

Contact

Director
Institute of Microbial Technology
Sector 39A, Chandigarh 160036
Telephone +91-172-2690785, 2690684
FAX +91-172-2690585, 2690132
Email : director@imtech.res.in

Equipment Usage Cost

Equipment

Cost /day Basis (pro rata basis)

Ultra/Microfiltration Unit

910.00

Ulrafiltration with tank

1820.00

Chromato graphic Systems

AKta Process (system I)

8185.00

AKta Avant system with accessories andcold cabinet

5455.00

Acta Purifier     

2000.00

Homogenizer

3820.00

Fermenters

Fermenter 5L  (Bioflo 110)

1365.00

Fermenter (40 L)

5000.00

Bioflo 115

1110.00

Scigenics 5 L

570.00

Scigenics 50 L

1190.00

Scigenics 500 L

1460.00

Note: the equipment usage charge is only one component of the total project cost and total project cost will be calculated case to case basis as per “CSIR Guidelines for Technology Transfer and Utilization of Knowledgebase-2017” 

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Last Updated: 30 Jan 2023