Genome integrity is precisely regulated in all organisms and DNA damage response (DDR) proteins are major players in this process. Mutation in DDR proteins cause developmental defects in patients that might relate to altered nuclear structure, chromatin architecture in physiological conditions .Environmental, exogenous/endogenous agents continuously damage human genome. The toxic effects of these factors induce lesions in DNA causing mutations and deletions in chromosomes resulting in genome instability that have immediate effect on cell function as well as long-term consequences. To counteract the deleterious effects of DNA lesions, cells have developed sophisticated genome caretaking mechanisms to overcome DNA damage through specialized network of DNA repair pathways regulated by DNA damage checkpoint proteins. These apical DNA damage checkpoint proteins regulate integrity of chromosomes through coordination of the cell cycle progression with DNA repair, DNA replication and recombination processes through induction of the DNA damage response (DDR). Improper repair of DSBs can lead to various developmental defects and become genesis of many modern diseases. Overall, we aim to investigate the canonical and non-canonical DNA damage checkpoint proteins function in maintenance of cell physiology in coordination with other cell processes including Autophagy (through distributing mechanical cues, maintainance of stem cell potency, coordinating DNA damage with transcriptional response) in response to changes in chromatin dynamics through various unknown mechanisms. Editorial Board : Mutagenesis Journal (Oxford University Press, U.K.) Ecancer medicalscience, U.K.

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