Cell Biology, Immunology and Biotherapeutics.
Previous research efforts of our laboratory were focused on two important aspects related to the diseases kala-azar and cancer. The first entailed characterization of host immune responses against drug-resistant or susceptible Leishmania parasites, the causative agents of kala-azar. The second research aspect in tumor immunobiology led us to identify c-Src and Bruton’s tyrosine kinase as potential targets for anti-cancer therapy. Efforts are ongoing to identify new receptor(s) mediating Leishmania infection. In addition, our translational activities include development of biosimilar therapeutic monoclonal antibodies for the treatment of autoimmune diseases and cancer. In brief, our ongoing work encompasses both fundamental and applied research on cancer, infectious and autoimmune diseases.
- Gujar, R., Maurya, N., Yadav, V., Gupta, M., Arora, S., Khatri, N., and Sen, P. (2016) c-Src Suppresses Dendritic Cell Antitumor Activity via T Cell Ig and Mucin Protein-3 Receptor. J. Immunol. 197, 1650-1662.
- Maurya, N., Gujar, R., Gupta, M., Yadav, V., Verma, S., and Sen, P. (2014) Immunoregulation of dendritic cells by the receptor T cell Ig and mucin protein-3 via Bruton's tyrosine kinase and c-Src. J. Immunol. 193, 3417-3425.
- Singhal, E., Kumar, P., and Sen, P. (2011) A novel role for Bruton's tyrosine kinase in hepatocyte growth factor-mediated immunoregulation of dendritic cells. J. Biol. Chem. 286, 32054-32063.
- Singhal, E., and Sen, P. (2011) Hepatocyte growth factor-induced c-Src-phosphatidylinositol 3-kinase-AKT-mammalian target of rapamycin pathway inhibits dendritic cell activation by blocking IkappaB kinase activity. Int. J. Biochem. Cell Biol. 43, 1134-1146.
- Haldar, A. K., Yadav, V., Singhal, E., Bisht, K. K., Singh, A., Bhaumik, S., Basu, R., Sen, P., and Roy, S. (2010) Leishmania donovani isolates with antimony-resistant but not -sensitive phenotype inhibit sodium antimony gluconate-induced dendritic cell activation. PLoS Pathog. 6, e1000907.