Chief Scientist:

Dr. Srikrishna Subramanian



Contact Address

P004, Ground Floor,


Protein Science, Bioinformatics, Computational Biology, Structural Biology, Microbial Genomics and Metagenomics, BIG DATA analytics.


Dr. Srikrishna Subramanian is a computational biologist with expertise in structural biology and microbial genomics. He has made several fundamental contributions in understanding how proteins evolve. At the CSIR-IMTECH, he is involved in projects under a common theme, viz., classifying protein structures by grouping them into evolutionarily meaningful families, and developing novel algorithms to assist in this process. He also has considerable expertise in microbial genomics and metagenomics. His primary research interests are to understand the prevalent mechanisms by which genes and proteins evolve and use this knowledge, inferred from insightful analysis, to better understand the roles of these macromolecules in their respective organisms. He is Associate Editor of the BMC journals, Biology Direct and BMC Bioinformatics. He is also a member of the DBT taskforce on Genome Editing Technologies and a Scientific Advisory Board member of the Chemical Probes portal.

Major Publications

  • Khatri, I., Tomar, R., Ganesan, K., Prasad, G., and Subramanian, S. (2017) Complete genome sequence and comparative genomics of the probiotic yeast Saccharomyces boulardii. Scientific Reports 7, 371.
  • Kaur, G., and Subramanian, S. (2016) Classification of the treble clef zinc finger: noteworthy lessons for structure and function evolution. Scientific reports 6.
  • Acharya, G., Kaur, G., and Subramanian, S. (2016) An atypical segment swap in the DN and DC domains of the Acr_tran family resistance-nodulation-cell division pump. Journal of structural biology 196, 358-363.
  • Kaur, G., and Subramanian, S. (2014) Repurposing TRASH: Emergence of the enzyme organomercurial lyase from a non-catalytic zinc finger scaffold. Journal of structural biology 188, 16-21.
  • Kaur, G., and Subramanian, S. (2015) The insertion domain 1 of class IIA dimeric glycyl-tRNA synthetase is a rubredoxin-like zinc ribbon. Journal of structural biology 190, 38-46.

Lab Members